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Sterol regulatory element-binding protein cleavage-activating protein

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Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

Below are the list of possible Sterol regulatory element-binding protein cleavage-activating protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Sterol regulatory element-binding protein cleavage-activating protein

 Sterol regulatory element-binding protein cleavage-activating protein ELISA Kit
 Sterol regulatory element-binding protein cleavage-activating protein Recombinant
 Sterol regulatory element-binding protein cleavage-activating protein Antibody
Also known as Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein).
SCAP: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in S
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CAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Belongs to the WD repeat SCAP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; protein complex

Molecular Function: protein complex binding

Biological Process: aging; cholesterol metabolic process; regulation of cholesterol biosynthetic process; regulation of fatty acid biosynthetic process; regulation of fatty acid metabolic process; response to hypoxia; response to insulin stimulus; SREBP-mediated signaling pathway
 Scap ELISA Kit
 Scap Recombinant
 Scap Antibody
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