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Store-operated calcium entry-associated regulatory factor

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Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

Below are the list of possible Store-operated calcium entry-associated regulatory factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Store-operated calcium entry-associated regulatory factor

 Store-operated calcium entry-associated regulatory factor ELISA Kit
 Store-operated calcium entry-associated regulatory factor Recombinant
 Store-operated calcium entry-associated regulatory factor Antibody
Also known as Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66).
TMEM66: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently tu
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rn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Belongs to the SARAF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: integral to endoplasmic reticulum membrane

Molecular Function: protein binding
 SARAF ELISA Kit
 SARAF Recombinant
 SARAF Antibody
 TMEM66 ELISA Kit
 TMEM66 Recombinant
 TMEM66 Antibody
 XTP3 ELISA Kit
 XTP3 Recombinant
 XTP3 Antibody
 HSPC035 ELISA Kit
 HSPC035 Recombinant
 HSPC035 Antibody
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