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Stromal interaction molecule

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Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch.

Below are the list of possible Stromal interaction molecule products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Stromal interaction molecule 1

 Stromal interaction molecule 1 ELISA Kit
 Stromal interaction molecule 1 Recombinant
 Stromal interaction molecule 1 Antibody
STIM1: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. For
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ms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1. Ubiquitously expressed in various human primary cells and tumor cell lines.

Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral

Cellular Component: endoplasmic reticulum; growth cone; integral to endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; protein complex; sarcoplasmic reticulum membrane

Molecular Function: calcium channel regulator activity; calcium ion binding; identical protein binding; microtubule plus-end binding; protease binding; protein binding; store-operated calcium channel activity

Biological Process: activation of store-operated calcium channel activity; cation transport; cellular calcium ion homeostasis; detection of calcium ion; myotube differentiation; regulation of calcium ion transport
 Stim1 ELISA Kit
 Stim1 Recombinant
 Stim1 Antibody
 Sim ELISA Kit
 Sim Recombinant
 Sim Antibody
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Stromal interaction molecule 2

 Stromal interaction molecule 2 ELISA Kit
 Stromal interaction molecule 2 Recombinant
 Stromal interaction molecule 2 Antibody
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG)
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start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
 STIM2 ELISA Kit
 STIM2 Recombinant
 STIM2 Antibody
 KIAA1482 ELISA Kit
 KIAA1482 Recombinant
 KIAA1482 Antibody
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Stromal interaction molecule homolog

 Stromal interaction molecule homolog ELISA Kit
 Stromal interaction molecule homolog Recombinant
 Stromal interaction molecule homolog Antibody
Plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores.
 Stim ELISA Kit
 Stim Recombinant
 Stim Antibody
 CG9126 ELISA Kit
 CG9126 Recombinant
 CG9126 Antibody
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