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Structural maintenance of chromosomes protein 1B ELISA Kit Structural maintenance of chromosomes protein 1B Recombinant Structural maintenance of chromosomes protein 1B Antibody | Also known as Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B). SMC1B: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, rec >>> ombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SMC family. SMC1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Cellular Component: chromosome, pericentric region; condensed nuclear chromosome; cytoplasm; lateral element; nucleoplasm; synaptonemal complex
Molecular Function: DNA binding; protein binding
Biological Process: meiosis; sister chromatid cohesion |
Smc1b ELISA Kit Smc1b Recombinant Smc1b Antibody | Smc1l2 ELISA Kit Smc1l2 Recombinant Smc1l2 Antibody |
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