Structural maintenance of chromosomes protein

omplex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

ombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SMC family. SMC1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Cellular Component: chromosome, pericentric region; condensed nuclear chromosome; cytoplasm; lateral element; nucleoplasm; synaptonemal complex

Molecular Function: DNA binding; protein binding

Biological Process: meiosis; sister chromatid cohesion

hromatids after DNA replication (PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate ().

ays also an important role in spindle pole assembly during mitosis and in chromosomes movement ().