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Suppression of tumorigenicity 5 protein

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Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth (By similarity).

Below are the list of possible Suppression of tumorigenicity 5 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Suppression of tumorigenicity 5 protein

 Suppression of tumorigenicity 5 protein ELISA Kit
 Suppression of tumorigenicity 5 protein Recombinant
 Suppression of tumorigenicity 5 protein Antibody
Also known as Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B).
DENND2B: a guanine nucleotide exchange factor (GEF) that may activate RAB9A and RAB9B. May be involved in cytoskeletal organization and tumorogenicity. Widely expressed with the exception of peripheral blood lymphocytes and lymphoid cell lines. 3 isoforms of the human protein are produced by alternative p
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romoter. Isoform 1 interacts with the SH3 domain of ABL1, is expressed in several epithelial, fibroblast, and tumorigenic cell lines, and seems to be involved in the activation of ERK2. Isoform 3, expressed in primary cells that may be weakly tumorigenic, but not in tumorigenic cell lines, may block ERK2 activation stimulated by ABL1, and may alter cell morphology and cell growth.

Protein type: GEFs; GEFs, Rab

Molecular Function: Rab guanyl-nucleotide exchange factor activity
 St5 ELISA Kit
 St5 Recombinant
 St5 Antibody
 Dennd2b ELISA Kit
 Dennd2b Recombinant
 Dennd2b Antibody
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