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Suppressor of cytokine signaling

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SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).

Below are the list of possible Suppressor of cytokine signaling products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Suppressor of cytokine signaling 1

 Suppressor of cytokine signaling 1 ELISA Kit
 Suppressor of cytokine signaling 1 Recombinant
 Suppressor of cytokine signaling 1 Antibody
Also known as Suppressor of cytokine signaling 1 (SOCS-1).
suppressor of cytokine signalling [RGD, Feb 2006]
 Socs1 ELISA Kit
 Socs1 Recombinant
 Socs1 Antibody
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Suppressor of cytokine signaling 2

 Suppressor of cytokine signaling 2 ELISA Kit
 Suppressor of cytokine signaling 2 Recombinant
 Suppressor of cytokine signaling 2 Antibody
Also known as Suppressor of cytokine signaling 2 (SOCS-2).
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which media
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tes the ubiquitination and subsequent proteasomal degradation of target proteins ().
 SOCS2 ELISA Kit
 SOCS2 Recombinant
 SOCS2 Antibody
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Suppressor of cytokine signaling 3

 Suppressor of cytokine signaling 3 ELISA Kit
 Suppressor of cytokine signaling 3 Recombinant
 Suppressor of cytokine signaling 3 Antibody
Also known as Suppressor of cytokine signaling 3 (SOCS-3).
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin an
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d leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST ().
 SOCS3 ELISA Kit
 SOCS3 Recombinant
 SOCS3 Antibody
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Suppressor of cytokine signaling 4

 Suppressor of cytokine signaling 4 ELISA Kit
 Suppressor of cytokine signaling 4 Recombinant
 Suppressor of cytokine signaling 4 Antibody
Also known as Suppressor of cytokine signaling 4 (SOCS-4).
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibi
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ts EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR ().
 SOCS4 ELISA Kit
 SOCS4 Recombinant
 SOCS4 Antibody
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Suppressor of cytokine signaling 5

 Suppressor of cytokine signaling 5 ELISA Kit
 Suppressor of cytokine signaling 5 Recombinant
 Suppressor of cytokine signaling 5 Antibody
Also known as Suppressor of cytokine signaling 5 (SOCS-5).
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target protein
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s. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling ().
 SOCS5 ELISA Kit
 SOCS5 Recombinant
 SOCS5 Antibody
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Suppressor of cytokine signaling 6

 Suppressor of cytokine signaling 6 ELISA Kit
 Suppressor of cytokine signaling 6 Recombinant
 Suppressor of cytokine signaling 6 Antibody
Also known as Suppressor of cytokine signaling 6 (SOCS-6).
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target protein
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s. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor ().
 SOCS6 ELISA Kit
 SOCS6 Recombinant
 SOCS6 Antibody
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Suppressor of cytokine signaling 7

 Suppressor of cytokine signaling 7 ELISA Kit
 Suppressor of cytokine signaling 7 Recombinant
 Suppressor of cytokine signaling 7 Antibody
Also known as Suppressor of cytokine signaling 7 (SOCS-7).
SOCS7: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent pro
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teasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cerebral cortex radially oriented cell migration; cytokine and chemokine mediated signaling pathway; fat cell differentiation; insulin receptor signaling pathway; layer formation in the cerebral cortex; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; protein ubiquitination; radial glia guided migration of Purkinje cell
 Socs7 ELISA Kit
 Socs7 Recombinant
 Socs7 Antibody
 Cish7 ELISA Kit
 Cish7 Recombinant
 Cish7 Antibody
 Nap4 ELISA Kit
 Nap4 Recombinant
 Nap4 Antibody
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