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Suppressor of fused

Negative regulator in the hedgehog signaling pathway . Required for the proper formation of hair follicles and the control of epidermal differentiation.

Below are the list of possible Suppressor of fused products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Suppressor of fused homolog

 Suppressor of fused homolog ELISA Kit
 Suppressor of fused homolog Recombinant
 Suppressor of fused homolog Antibody
SUFU: a transcriptional regulator which negatively regulates the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. Modulates nuclear-cytoplasmic shuttling of Gli-1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the
cytoplasm, this effect is overcome by binding of FUSED to both SUFU and a GLI protein. Mutations in SUFU predispose to medulloblastoma. Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3. Part of a complex containing CTNNB1. Binds BTRC, GLI2, GLI3, SAP18 and STK36. Binds both free and DNA-bound GLI1. Defects in SUFU are a cause of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor

Cellular Component: cilium; cytoplasm; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; protein binding; protein kinase binding; signal transducer activity; transcription corepressor activity; transcription factor binding

Biological Process: cytoplasmic sequestering of transcription factor; determination of left/right symmetry; heart looping; negative regulation of smoothened signaling pathway; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; neural tube closure; skin development; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; spinal cord dorsal/ventral patterning
 Sufu ELISA Kit
 Sufu Recombinant
 Sufu Antibody
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