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Syntaxin-binding protein

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May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Below are the list of possible Syntaxin-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Syntaxin-binding protein 1

 Syntaxin-binding protein 1 ELISA Kit
 Syntaxin-binding protein 1 Recombinant
 Syntaxin-binding protein 1 Antibody
Also known as Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67).
STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in
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a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; plasma membrane; protein complex

Molecular Function: identical protein binding; protein binding; SNARE binding; syntaxin binding; syntaxin-1 binding

Biological Process: axon target recognition; glutamate secretion; negative regulation of synaptic transmission, GABAergic; neurotransmitter secretion; platelet degranulation; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic vesicle maturation; vesicle docking during exocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 4
 STXBP1 ELISA Kit
 STXBP1 Recombinant
 STXBP1 Antibody
 UNC18A ELISA Kit
 UNC18A Recombinant
 UNC18A Antibody
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Syntaxin-binding protein 2

 Syntaxin-binding protein 2 ELISA Kit
 Syntaxin-binding protein 2 Recombinant
 Syntaxin-binding protein 2 Antibody
Also known as Syntaxin-binding protein 2 (MUSEC1) (Protein unc-18 homolog 2) (Munc18-2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B).
STXBP2: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regula
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te membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. Defects in STXBP2 are the cause of familial hemophagocytic lymphohistiocytosis type 5 (FHL5). FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. Belongs to the STXBP/unc-18/SEC1 family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: apical plasma membrane; azurophil granule; cytoplasm; cytosol; lamellipodium; plasma membrane; protein complex; secretory granule; SNARE complex; specific granule; zymogen granule membrane

Molecular Function: protein binding; syntaxin binding; syntaxin-1 binding; syntaxin-3 binding

Biological Process: exocytosis; leukocyte mediated cytotoxicity; regulation of mast cell degranulation
 Stxbp2 ELISA Kit
 Stxbp2 Recombinant
 Stxbp2 Antibody
 Unc18b ELISA Kit
 Unc18b Recombinant
 Unc18b Antibody
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Syntaxin-binding protein 3

 Syntaxin-binding protein 3 ELISA Kit
 Syntaxin-binding protein 3 Recombinant
 Syntaxin-binding protein 3 Antibody
Also known as Syntaxin-binding protein 3 (MUNC-18-3) (Mammalian homolog of Unc-18c) (Munc-18c) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C).
STXBP3: a vesicle protein that, together with STX4 and VAMP2, regulates the insulin-dependent movement of GLUT4 and the docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Reduction in its expression using siRNA impairs insulin-stimulated GLUT4 vesicle exocytosis in 3T3-L1 adipocytes. Phosphorylated by the insulin receptor (InsR) at Tyr521 in vitro, and bound and phosphorylated by
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the activated InsR within adipocytes and skeletal muscle. Tyrosine phosphorylation on residues Y219 and Y521 correlates with its dissociation from STX4. Phosphorylated by PKC in platelets in response to thrombin stimulation, inhibiting its binding to STX4. Interacts directly with DOC2B at the cell membrane, excluding its interaction with STX4, regulating glucose-stimulated insulin secretion. Belongs to the STXBP/unc-18/SEC1 family.

Protein type: Vesicle

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytosol; plasma membrane; specific granule

Molecular Function: protein binding; syntaxin binding; syntaxin-1 binding

Biological Process: brain development; exocytosis; glucose transport; insulin secretion; negative regulation of calcium ion-dependent exocytosis; protein heterooligomerization; protein to membrane docking; response to insulin stimulus
 Stxbp3 ELISA Kit
 Stxbp3 Recombinant
 Stxbp3 Antibody
 Stxbp3a ELISA Kit
 Stxbp3a Recombinant
 Stxbp3a Antibody
 Unc18c ELISA Kit
 Unc18c Recombinant
 Unc18c Antibody
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Syntaxin-binding protein 4

 Syntaxin-binding protein 4 ELISA Kit
 Syntaxin-binding protein 4 Recombinant
 Syntaxin-binding protein 4 Antibody
Also known as Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip).
STXBP4: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with in
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sulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. Interacts with STX4A. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Cellular Component: cytoplasm; intermediate filament cytoskeleton; nucleoplasm

Molecular Function: protein binding; syntaxin binding

Biological Process: glucose transport; insulin receptor signaling pathway; protein stabilization; protein targeting; response to DNA damage stimulus
 Stxbp4 ELISA Kit
 Stxbp4 Recombinant
 Stxbp4 Antibody
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Syntaxin-binding protein 5

 Syntaxin-binding protein 5 ELISA Kit
 Syntaxin-binding protein 5 Recombinant
 Syntaxin-binding protein 5 Antibody
Also known as Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1).
STXBP5: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of
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GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding. Belongs to the WD repeat L(2)GL family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Cellular Component: cytoplasm; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; secretory granule; SNARE complex

Molecular Function: GTPase activator activity; Rab GTPase binding; syntaxin binding; syntaxin-1 binding

Biological Process: exocytosis; positive regulation of exocytosis; regulation of blood coagulation; regulation of exocytosis; regulation of gene expression; regulation of protein secretion
 Stxbp5 ELISA Kit
 Stxbp5 Recombinant
 Stxbp5 Antibody
 Llgl3 ELISA Kit
 Llgl3 Recombinant
 Llgl3 Antibody
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Syntaxin-binding protein 5-like

 Syntaxin-binding protein 5-like ELISA Kit
 Syntaxin-binding protein 5-like Recombinant
 Syntaxin-binding protein 5-like Antibody
May play a role in vesicle trafficking and exocytosis.
 stxbp5l ELISA Kit
 stxbp5l Recombinant
 stxbp5l Antibody
 si:ch211-194d6.1 ELISA Kit
 si:ch211-194d6.1 Recombinant
 si:ch211-194d6.1 Antibody
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Syntaxin-binding protein 6

 Syntaxin-binding protein 6 ELISA Kit
 Syntaxin-binding protein 6 Recombinant
 Syntaxin-binding protein 6 Antibody
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
 STXBP6 ELISA Kit
 STXBP6 Recombinant
 STXBP6 Antibody
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