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Tankyrase

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Stimulates proteasome activity, probably by ADP-ribosylation of PI31. Modulates 26S proteasome assembly.

Below are the list of possible Tankyrase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tankyrase

 Tankyrase ELISA Kit
 Tankyrase Recombinant
 Tankyrase Antibody
Also known as Tankyrase (dTNKS) (Poly [ADP-ribose] polymerase).
Stimulates proteasome activity, probably by ADP-ribosylation of PI31. Modulates 26S proteasome assembly.
 Tnks ELISA Kit
 Tnks Recombinant
 Tnks Antibody
 tankyrase ELISA Kit
 tankyrase Recombinant
 tankyrase Antibody
 CG4719 ELISA Kit
 CG4719 Recombinant
 CG4719 Antibody
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Tankyrase-1

 Tankyrase-1 ELISA Kit
 Tankyrase-1 Recombinant
 Tankyrase-1 Antibody
Also known as Tankyrase-1 (TANK1) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I).
TNKS: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates
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their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.30; Transferase

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: chromosome, telomeric region; cytosol; Golgi apparatus; nuclear chromosome, telomeric region; nuclear membrane; nuclear pore; pericentriolar material

Molecular Function: histone binding; NAD+ ADP-ribosyltransferase activity; protein binding; zinc ion binding

Biological Process: mitotic spindle organization and biogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; protein amino acid ADP-ribosylation; protein polyubiquitination; regulation of telomere maintenance via telomerase; spindle assembly; Wnt receptor signaling pathway
 TNKS ELISA Kit
 TNKS Recombinant
 TNKS Antibody
 PARP5A ELISA Kit
 PARP5A Recombinant
 PARP5A Antibody
 PARPL ELISA Kit
 PARPL Recombinant
 PARPL Antibody
 TIN1 ELISA Kit
 TIN1 Recombinant
 TIN1 Antibody
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Tankyrase-2

 Tankyrase-2 ELISA Kit
 Tankyrase-2 Recombinant
 Tankyrase-2 Antibody
Also known as Tankyrase-2 (TANK2) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related pro.
TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins ar
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e recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Protein type: EC 2.4.2.30; Nuclear envelope; Transferase

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: cytoplasm; cytosol; nuclear chromosome, telomeric region; nuclear envelope; nucleus; pericentriolar material; perinuclear region of cytoplasm

Molecular Function: enzyme binding; NAD+ ADP-ribosyltransferase activity; protein binding

Biological Process: positive regulation of telomere maintenance via telomerase; protein amino acid ADP-ribosylation; protein polyubiquitination; Wnt receptor signaling pathway
 TNKS2 ELISA Kit
 TNKS2 Recombinant
 TNKS2 Antibody
 PARP5B ELISA Kit
 PARP5B Recombinant
 PARP5B Antibody
 TANK2 ELISA Kit
 TANK2 Recombinant
 TANK2 Antibody
 TNKL ELISA Kit
 TNKL Recombinant
 TNKL Antibody
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