Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Target of rapamycin complex  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ancylostoma duodenale PCR Kit
 • acrolein (ACR) ELISA Kit
 • Smad4 Antibody
 • T Lymphocyte Subpopulation Cd3-4-8 (TLS) ELISA Kit
 • SAP130 Antibody
 • mucin 16, cell surface associated (CA125) ELISA Kit
 • prefoldin subunit 2 (PFDN2) Antibody
 • Activator of apoptosis harakiri (HRK) ELISA Kit
 • Actin like protein 8 (ACTL8) ELISA Kit
 • galactosidase, alpha (GLA) ELISA Kit
 • Chemokine C-C-Motif Receptor 1 (CCR1) ELISA Kit
 • zinc finger protein 410 (ZNF410) Antibody
 • Apolipoprotein A-I (APOA1) Antibody
 • Monocyte chemotactic protein 1-monocyte chemotactic and acti... ELISA Kit
 downarrow more ...
separator

Target of rapamycin complex

separator
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.

Below are the list of possible Target of rapamycin complex products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Target of rapamycin complex 1 subunit KOG1

 Target of rapamycin complex 1 subunit KOG1 ELISA Kit
 Target of rapamycin complex 1 subunit KOG1 Recombinant
 Target of rapamycin complex 1 subunit KOG1 Antibody
Also known as Target of rapamycin complex 1 subunit KOG1 (TORC1 subunit KOG1) (Kontroller of growth protein 1) (Local anesthetic-sensitive protein 24).
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiat
>>>
ion factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.
 KOG1 ELISA Kit
 KOG1 Recombinant
 KOG1 Antibody
 LAS24 ELISA Kit
 LAS24 Recombinant
 LAS24 Antibody
 YHR186C ELISA Kit
 YHR186C Recombinant
 YHR186C Antibody
 H9998.14 ELISA Kit
 H9998.14 Recombinant
 H9998.14 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 1 subunit mip1

 Target of rapamycin complex 1 subunit mip1 ELISA Kit
 Target of rapamycin complex 1 subunit mip1 Recombinant
 Target of rapamycin complex 1 subunit mip1 Antibody
Also known as Target of rapamycin complex 1 subunit mip1 (TORC1 subunit mip1).
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulatin
>>>
g ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
 mip1 ELISA Kit
 mip1 Recombinant
 mip1 Antibody
 SPAC57A7.11 ELISA Kit
 SPAC57A7.11 Recombinant
 SPAC57A7.11 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 1 subunit tco89

 Target of rapamycin complex 1 subunit tco89 ELISA Kit
 Target of rapamycin complex 1 subunit tco89 Recombinant
 Target of rapamycin complex 1 subunit tco89 Antibody
Also known as Target of rapamycin complex 1 subunit tco89 (TORC1 subunit tco89).
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering wit
>>>
h the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
 tco89 ELISA Kit
 tco89 Recombinant
 tco89 Antibody
 SPCC162.12 ELISA Kit
 SPCC162.12 Recombinant
 SPCC162.12 Antibody
 SPCC1753.06c ELISA Kit
 SPCC1753.06c Recombinant
 SPCC1753.06c Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 1 subunit toc1

 Target of rapamycin complex 1 subunit toc1 ELISA Kit
 Target of rapamycin complex 1 subunit toc1 Recombinant
 Target of rapamycin complex 1 subunit toc1 Antibody
Also known as Target of rapamycin complex 1 subunit toc1 (TORC1 subunit toc1).
Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulatin
>>>
g ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.
 toc1 ELISA Kit
 toc1 Recombinant
 toc1 Antibody
 SPBP18G5.03 ELISA Kit
 SPBP18G5.03 Recombinant
 SPBP18G5.03 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit AVO1

 Target of rapamycin complex 2 subunit AVO1 ELISA Kit
 Target of rapamycin complex 2 subunit AVO1 Recombinant
 Target of rapamycin complex 2 subunit AVO1 Antibody
Also known as Target of rapamycin complex 2 subunit AVO1 (TORC2 subunit AVO1) (Adheres voraciously to TOR2 protein 1).
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
 AVO1 ELISA Kit
 AVO1 Recombinant
 AVO1 Antibody
 YOL078W ELISA Kit
 YOL078W Recombinant
 YOL078W Antibody
 O1110 ELISA Kit
 O1110 Recombinant
 O1110 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit AVO2

 Target of rapamycin complex 2 subunit AVO2 ELISA Kit
 Target of rapamycin complex 2 subunit AVO2 Recombinant
 Target of rapamycin complex 2 subunit AVO2 Antibody
Also known as Target of rapamycin complex 2 subunit AVO2 (TORC2 subunit AVO2) (Adheres voraciously to TOR2 protein 2).
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
 AVO2 ELISA Kit
 AVO2 Recombinant
 AVO2 Antibody
 YMR068W ELISA Kit
 YMR068W Recombinant
 YMR068W Antibody
 YM9916.07 ELISA Kit
 YM9916.07 Recombinant
 YM9916.07 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit bit61

 Target of rapamycin complex 2 subunit bit61 ELISA Kit
 Target of rapamycin complex 2 subunit bit61 Recombinant
 Target of rapamycin complex 2 subunit bit61 Antibody
Also known as Target of rapamycin complex 2 subunit bit61 (TORC2 subunit bit61).
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid
>>>
uptake through the control of expression of amino acid permeases.
 bit61 ELISA Kit
 bit61 Recombinant
 bit61 Antibody
 SPCC777.08c ELISA Kit
 SPCC777.08c Recombinant
 SPCC777.08c Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit MAPKAP1

 Target of rapamycin complex 2 subunit MAPKAP1 ELISA Kit
 Target of rapamycin complex 2 subunit MAPKAP1 Recombinant
 Target of rapamycin complex 2 subunit MAPKAP1 Antibody
Also known as Target of rapamycin complex 2 subunit MAPKAP1 (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1).
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTO
>>>
RC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex ().
 MAPKAP1 ELISA Kit
 MAPKAP1 Recombinant
 MAPKAP1 Antibody
 SIN1 ELISA Kit
 SIN1 Recombinant
 SIN1 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit sin1

 Target of rapamycin complex 2 subunit sin1 ELISA Kit
 Target of rapamycin complex 2 subunit sin1 Recombinant
 Target of rapamycin complex 2 subunit sin1 Antibody
Also known as Target of rapamycin complex 2 subunit sin1 (TORC2 subunit sin1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1).
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arr
>>>
est, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases.
 sin1 ELISA Kit
 sin1 Recombinant
 sin1 Antibody
 SPAPYUG7.02c ELISA Kit
 SPAPYUG7.02c Recombinant
 SPAPYUG7.02c Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit ste20

 Target of rapamycin complex 2 subunit ste20 ELISA Kit
 Target of rapamycin complex 2 subunit ste20 Recombinant
 Target of rapamycin complex 2 subunit ste20 Antibody
Also known as Target of rapamycin complex 2 subunit ste20 (TORC2 subunit ste20).
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid
>>>
uptake through the control of expression of amino acid permeases.
 ste20 ELISA Kit
 ste20 Recombinant
 ste20 Antibody
 SPBC12C2.02c ELISA Kit
 SPBC12C2.02c Recombinant
 SPBC12C2.02c Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex 2 subunit TSC11

 Target of rapamycin complex 2 subunit TSC11 ELISA Kit
 Target of rapamycin complex 2 subunit TSC11 Recombinant
 Target of rapamycin complex 2 subunit TSC11 Antibody
Also known as Target of rapamycin complex 2 subunit TSC11 (TORC2 subunit TSC11) (Adheres voraciously to TOR2 protein 3) (Temperature-sensitive CSG2 suppressor protein 11).
Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AV
>>>
O2 and SLM1.
 TSC11 ELISA Kit
 TSC11 Recombinant
 TSC11 Antibody
 AVO3 ELISA Kit
 AVO3 Recombinant
 AVO3 Antibody
 YER093C ELISA Kit
 YER093C Recombinant
 YER093C Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex subunit LST8

 Target of rapamycin complex subunit LST8 ELISA Kit
 Target of rapamycin complex subunit LST8 Recombinant
 Target of rapamycin complex subunit LST8 Antibody
Also known as Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8).
LST8: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-si
>>>
gnaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient- poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum- induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12- rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Broadly expressed, with highest levels in skeletal muscle, heart and kidney. Belongs to the WD repeat LST8 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; TORC2 complex

Molecular Function: protein binding; protein serine/threonine kinase activator activity

Biological Process: cell cycle arrest; macroautophagy; phosphoinositide-mediated signaling; positive regulation of TOR signaling pathway; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation
 MLST8 ELISA Kit
 MLST8 Recombinant
 MLST8 Antibody
 GBL ELISA Kit
 GBL Recombinant
 GBL Antibody
 LST8 ELISA Kit
 LST8 Recombinant
 LST8 Antibody
Table BarTOPTable Bar
 

Target of rapamycin complex subunit wat1

 Target of rapamycin complex subunit wat1 ELISA Kit
 Target of rapamycin complex subunit wat1 Recombinant
 Target of rapamycin complex subunit wat1 Antibody
Also known as Target of rapamycin complex subunit wat1 (TORC subunit wat1) (WD repeat-containing protein pop3).
component of both TORC1 and TORC2, which regulate multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by
>>>
interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases (PubMed:17046992, PubMed:18076573, PubMed:17261596). May play a role in mRNA maturation as a coupling protein between splicing and synthesis and/or stabilization.
 pop3 ELISA Kit
 pop3 Recombinant
 pop3 Antibody
 wat1 ELISA Kit
 wat1 Recombinant
 wat1 Antibody
 SPBC21B10.05c ELISA Kit
 SPBC21B10.05c Recombinant
 SPBC21B10.05c Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions