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Targeting protein

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Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

Below are the list of possible Targeting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Targeting protein for Xklp2

 Targeting protein for Xklp2 ELISA Kit
 Targeting protein for Xklp2 Recombinant
 Targeting protein for Xklp2 Antibody
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactiv
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ated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
 TPX2 ELISA Kit
 TPX2 Recombinant
 TPX2 Antibody
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Targeting protein for Xklp2 homolog

 Targeting protein for Xklp2 homolog ELISA Kit
 Targeting protein for Xklp2 homolog Recombinant
 Targeting protein for Xklp2 homolog Antibody
Also known as Targeting protein for Xklp2 homolog (TPX2 homolog) (Microtubule-associated protein TPX2 homolog).
Spindle assembly factor. Required for normal assembly of mitotic spindles ().
 TPX2 ELISA Kit
 TPX2 Recombinant
 TPX2 Antibody
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Targeting protein for Xklp2-A

 Targeting protein for Xklp2-A ELISA Kit
 Targeting protein for Xklp2-A Recombinant
 Targeting protein for Xklp2-A Antibody
TPX2: a microtubule-associated protein required for meiotic and mitotic spindle assembly. Targets a plus end-directed motor (XKLP2) to the minus ends of microtubules in the mitotic spindle. Required for microtubule nucleation around chromosomes in response to the local generation of RanGTP. Binds to and activates Aurora A kinase and targets it to the mitotic spindle

Protein type: Cell cycl
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e regulation; Microtubule-binding
 tpx2-a ELISA Kit
 tpx2-a Recombinant
 tpx2-a Antibody
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Targeting protein for Xklp2-B

 Targeting protein for Xklp2-B ELISA Kit
 Targeting protein for Xklp2-B Recombinant
 Targeting protein for Xklp2-B Antibody
Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activates aurka by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation ().
 tpx2-b ELISA Kit
 tpx2-b Recombinant
 tpx2-b Antibody
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Proteins Root Name Listing
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