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Tartrate-resistant acid phosphatase

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Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Below are the list of possible Tartrate-resistant acid phosphatase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tartrate-resistant acid phosphatase type 5

 Tartrate-resistant acid phosphatase type 5 ELISA Kit
 Tartrate-resistant acid phosphatase type 5 Recombinant
 Tartrate-resistant acid phosphatase type 5 Antibody
Also known as Tartrate-resistant acid phosphatase type 5 (TR-AP) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase).
ACP5: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Defects in ACP5 are the cause of spond
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yloenchondrodysplasia with immune dysregulation (SPENCDI). A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytosol; integral to membrane

Molecular Function: acid phosphatase activity; ferric iron binding; ferrous iron binding

Biological Process: riboflavin metabolic process

Disease: Spondyloenchondrodysplasia With Immune Dysregulation
 ACP5 ELISA Kit
 ACP5 Recombinant
 ACP5 Antibody
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