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Tectonic

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Below are the list of possible Tectonic products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tectonic

 Tectonic ELISA Kit
 Tectonic Recombinant
 Tectonic Antibody
Also known as Tectonic (dTectonic).
 tectonic ELISA Kit
 tectonic Recombinant
 tectonic Antibody
 Tect ELISA Kit
 Tect Recombinant
 Tect Antibody
 CG9227 ELISA Kit
 CG9227 Recombinant
 CG9227 Antibody
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Tectonic-1

 Tectonic-1 ELISA Kit
 Tectonic-1 Recombinant
 Tectonic-1 Antibody
TCTN1: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the path
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way in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23. Defects in TCTN1 are the cause of Joubert syndrome type 13 (JBTS13). JBTS13 is a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the tectonic family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: cytosol

Disease: Joubert Syndrome 13
 TCTN1 ELISA Kit
 TCTN1 Recombinant
 TCTN1 Antibody
 TECT1 ELISA Kit
 TECT1 Recombinant
 TECT1 Antibody
 UNQ9369/PRO34160 ELISA Kit
 UNQ9369/PRO34160 Recombinant
 UNQ9369/PRO34160 Antibody
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Tectonic-2

 Tectonic-2 ELISA Kit
 Tectonic-2 Recombinant
 Tectonic-2 Antibody
TCTN2: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction. Defects in TCTN2 are the cause of Meckel syndrome type 8 (MKS8). A disorder characterized by a combination of renal cysts and variabl
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y associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Defects in TCTN2 may be a cause of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the tectonic family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Molecular Function: protein binding

Biological Process: smoothened signaling pathway
 Tctn2 ELISA Kit
 Tctn2 Recombinant
 Tctn2 Antibody
 Tect2 ELISA Kit
 Tect2 Recombinant
 Tect2 Antibody
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Tectonic-3

 Tectonic-3 ELISA Kit
 Tectonic-3 Recombinant
 Tectonic-3 Antibody
TCTN3: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation. Belongs to the tectonic family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24.1

Biological Process: smoothened signaling pathway

Disease: Joubert Syndrome 1; Joubert Syndrome 18; Orofaciodigital Syndrome Iv
 TCTN3 ELISA Kit
 TCTN3 Recombinant
 TCTN3 Antibody
 C10orf61 ELISA Kit
 C10orf61 Recombinant
 C10orf61 Antibody
 TECT3 ELISA Kit
 TECT3 Recombinant
 TECT3 Antibody
 PSEC0041 ELISA Kit
 PSEC0041 Recombinant
 PSEC0041 Antibody
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