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Telomerase-binding protein

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Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (By similarity).

Below are the list of possible Telomerase-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Telomerase-binding protein EST1A

 Telomerase-binding protein EST1A ELISA Kit
 Telomerase-binding protein EST1A Recombinant
 Telomerase-binding protein EST1A Antibody
Also known as Telomerase-binding protein EST1A (EST1-like protein A) (Ever shorter telomeres 1A) (Smg-6 homolog) (Telomerase subunit EST1A).
EST1A: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'- (GTGTGG)(4)GTGT-3
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' telomeric DNA, but not to a telomerase RNA template component (TER). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; EC 3.1.-.-; Hydrolase; Nucleolus

Cellular Component: cytoplasm; cytosol; nucleolus; nucleus; telomerase holoenzyme complex

Molecular Function: endoribonuclease activity; ribonuclease activity; ribonucleoprotein binding; telomeric DNA binding

Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; regulation of RNA stability; telomere maintenance; telomere maintenance via telomerase
 Smg6 ELISA Kit
 Smg6 Recombinant
 Smg6 Antibody
 Est1a ELISA Kit
 Est1a Recombinant
 Est1a Antibody
 Kiaa0732 ELISA Kit
 Kiaa0732 Recombinant
 Kiaa0732 Antibody
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