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TERF1-interacting nuclear factor

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Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity).

Below are the list of possible TERF1-interacting nuclear factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TERF1-interacting nuclear factor 2

 TERF1-interacting nuclear factor 2 ELISA Kit
 TERF1-interacting nuclear factor 2 Recombinant
 TERF1-interacting nuclear factor 2 Antibody
Also known as TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2).
TINF2: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from t
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he DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. Defects in TINF2 are a cause of dyskeratosis congenita autosomal dominant type 3 (DKCA3). A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. Defects in TINF2 are a cause of retinopathy exudative with bone marrow failure (ERBMF); also known as Revesz syndrome. ERBMF is characterized by bilateral exudative retinopathy, bone marrow hypoplasia, nail dystrophy, fine hair, cerebellar hypoplasia, and growth retardation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Cellular Component: chromosome, telomeric region; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: negative regulation of epithelial cell proliferation; negative regulation of telomerase activity; negative regulation of telomere maintenance; negative regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance; telomere assembly
 Tinf2 ELISA Kit
 Tinf2 Recombinant
 Tinf2 Antibody
 Tin2 ELISA Kit
 Tin2 Recombinant
 Tin2 Antibody
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