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TGF-beta-activated kinase 1 and MAP3K7-binding protein

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May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Below are the list of possible TGF-beta-activated kinase 1 and MAP3K7-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 ELISA Kit
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Recombinant
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Antibody
Also known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).
TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Inte
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racts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Activator; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; nucleoplasm; protein complex

Molecular Function: kinase activator activity; mitogen-activated protein kinase p38 binding; protein binding; protein complex binding

Biological Process: activation of MAPKKK activity; heart morphogenesis; in utero embryonic development; lung development; positive regulation of MAP kinase activity; transforming growth factor beta receptor signaling pathway
 Tab1 ELISA Kit
 Tab1 Recombinant
 Tab1 Antibody
 Map3k7ip1 ELISA Kit
 Map3k7ip1 Recombinant
 Map3k7ip1 Antibody
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 ELISA Kit
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Recombinant
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Antibody
Also known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2).
TAB2: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked p
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olyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Molecular Function: protein binding

Biological Process: heart development; positive regulation of protein kinase activity
 Tab2 ELISA Kit
 Tab2 Recombinant
 Tab2 Antibody
 Kiaa0733 ELISA Kit
 Kiaa0733 Recombinant
 Kiaa0733 Antibody
 Map3k7ip2 ELISA Kit
 Map3k7ip2 Recombinant
 Map3k7ip2 Antibody
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 ELISA Kit
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 Recombinant
 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 Antibody
Also known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3).
TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways.
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Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane

Molecular Function: protein binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway
 TAB3 ELISA Kit
 TAB3 Recombinant
 TAB3 Antibody
 MAP3K7IP3 ELISA Kit
 MAP3K7IP3 Recombinant
 MAP3K7IP3 Antibody
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