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THAP domain-containing protein

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DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).

Below are the list of possible THAP domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

THAP domain-containing protein 1

 THAP domain-containing protein 1 ELISA Kit
 THAP domain-containing protein 1 Recombinant
 THAP domain-containing protein 1 Antibody
THAP1: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. M
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ay also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Defects in THAP1 are the cause of dystonia type 6 (DYT6). DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions. Belongs to the THAP1 family.

Protein type: Cell cycle regulation; DNA-binding; Transcription factor

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function: identical protein binding; sequence-specific DNA binding; zinc ion binding

Biological Process: endothelial cell proliferation; regulation of mitotic cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent
 Thap1 ELISA Kit
 Thap1 Recombinant
 Thap1 Antibody
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THAP domain-containing protein 1 A

 THAP domain-containing protein 1 A ELISA Kit
 THAP domain-containing protein 1 A Recombinant
 THAP domain-containing protein 1 A Antibody
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes ().
 thap1-a ELISA Kit
 thap1-a Recombinant
 thap1-a Antibody
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THAP domain-containing protein 1 B

 THAP domain-containing protein 1 B ELISA Kit
 THAP domain-containing protein 1 B Recombinant
 THAP domain-containing protein 1 B Antibody
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes ().
 thap1-b ELISA Kit
 thap1-b Recombinant
 thap1-b Antibody
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THAP domain-containing protein 10

 THAP domain-containing protein 10 ELISA Kit
 THAP domain-containing protein 10 Recombinant
 THAP domain-containing protein 10 Antibody
THAP10:

Chromosomal Location of Human Ortholog: 15q23

Molecular Function: protein binding
 THAP10 ELISA Kit
 THAP10 Recombinant
 THAP10 Antibody
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THAP domain-containing protein 11

 THAP domain-containing protein 11 ELISA Kit
 THAP domain-containing protein 11 Recombinant
 THAP domain-containing protein 11 Antibody
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers ().
 thap11 ELISA Kit
 thap11 Recombinant
 thap11 Antibody
 zgc:65871 ELISA Kit
 zgc:65871 Recombinant
 zgc:65871 Antibody
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THAP domain-containing protein 2

 THAP domain-containing protein 2 ELISA Kit
 THAP domain-containing protein 2 Recombinant
 THAP domain-containing protein 2 Antibody
THAP2:

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: nucleolus
 THAP2 ELISA Kit
 THAP2 Recombinant
 THAP2 Antibody
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THAP domain-containing protein 3

 THAP domain-containing protein 3 ELISA Kit
 THAP domain-containing protein 3 Recombinant
 THAP domain-containing protein 3 Antibody
THAP3: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p36.31

Molecular Function: protein binding
 THAP3 ELISA Kit
 THAP3 Recombinant
 THAP3 Antibody
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THAP domain-containing protein 4

 THAP domain-containing protein 4 ELISA Kit
 THAP domain-containing protein 4 Recombinant
 THAP domain-containing protein 4 Antibody
THAP4: 2 isoforms of the human protein are produced by alternative splicing.
 Thap4 ELISA Kit
 Thap4 Recombinant
 Thap4 Antibody
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THAP domain-containing protein 5

 THAP domain-containing protein 5 ELISA Kit
 THAP domain-containing protein 5 Recombinant
 THAP domain-containing protein 5 Antibody
Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.
 THAP5 ELISA Kit
 THAP5 Recombinant
 THAP5 Antibody
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THAP domain-containing protein 6

 THAP domain-containing protein 6 ELISA Kit
 THAP domain-containing protein 6 Recombinant
 THAP domain-containing protein 6 Antibody
THAP6: 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: microtubule cytoskeleton

Molecular Function: protein binding
 THAP6 ELISA Kit
 THAP6 Recombinant
 THAP6 Antibody
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THAP domain-containing protein 7

 THAP domain-containing protein 7 ELISA Kit
 THAP domain-containing protein 7 Recombinant
 THAP domain-containing protein 7 Antibody
THAP7: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: nuclear speck

Molecular Function: identical protein binding; protein binding; protein N-terminus
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binding

Biological Process: negative regulation of transcription, DNA-dependent
 THAP7 ELISA Kit
 THAP7 Recombinant
 THAP7 Antibody
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THAP domain-containing protein 8

 THAP domain-containing protein 8 ELISA Kit
 THAP domain-containing protein 8 Recombinant
 THAP domain-containing protein 8 Antibody
THAP8:

Chromosomal Location of Human Ortholog: 19q13.12

Molecular Function: protein binding
 THAP8 ELISA Kit
 THAP8 Recombinant
 THAP8 Antibody
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