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Three-prime repair exonuclease

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Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).

Below are the list of possible Three-prime repair exonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Three prime repair exonuclease 2

 Three prime repair exonuclease 2 ELISA Kit
 Three prime repair exonuclease 2 Recombinant
 Three prime repair exonuclease 2 Antibody
Also known as Three prime repair exonuclease 2 (3'-5' exonuclease TREX2).
TREX2: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Belongs to the exonuclease superfamily. TREX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Deoxyribonuclease; EC 3.1.11.2

M
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olecular Function: 3'-5'-exodeoxyribonuclease activity; magnesium ion binding; protein homodimerization activity

Biological Process: DNA metabolic process
 Trex2 ELISA Kit
 Trex2 Recombinant
 Trex2 Antibody
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Three-prime repair exonuclease 1

 Three-prime repair exonuclease 1 ELISA Kit
 Three-prime repair exonuclease 1 Recombinant
 Three-prime repair exonuclease 1 Antibody
Also known as Three-prime repair exonuclease 1 (3'-5' exonuclease TREX1).
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA
>>>
fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair ().
 TREX1 ELISA Kit
 TREX1 Recombinant
 TREX1 Antibody
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