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Tight junction protein

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The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity).

Below are the list of possible Tight junction protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tight junction protein ZO-1

 Tight junction protein ZO-1 ELISA Kit
 Tight junction protein ZO-1 Recombinant
 Tight junction protein ZO-1 Antibody
Also known as Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1).
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migratio
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n by targeting CDC42BPB to the leading edge of migrating cells ().
 TJP1 ELISA Kit
 TJP1 Recombinant
 TJP1 Antibody
 ZO1 ELISA Kit
 ZO1 Recombinant
 ZO1 Antibody
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Tight junction protein ZO-2

 Tight junction protein ZO-2 ELISA Kit
 Tight junction protein ZO-2 Recombinant
 Tight junction protein ZO-2 Antibody
Also known as Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2).
ZO2: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus.
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TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues..

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q13-q21

Cellular Component: cell junction; cell-cell adherens junction; cytoplasm; cytosol; nucleoplasm; plasma membrane; tight junction

Molecular Function: guanylate kinase activity; protein binding; protein binding, bridging; protein domain specific binding

Biological Process: intestinal absorption

Disease: Cholestasis, Progressive Familial Intrahepatic, 4; Hypercholanemia, Familial
 TJP2 ELISA Kit
 TJP2 Recombinant
 TJP2 Antibody
 X104 ELISA Kit
 X104 Recombinant
 X104 Antibody
 ZO2 ELISA Kit
 ZO2 Recombinant
 ZO2 Antibody
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Tight junction protein ZO-3

 Tight junction protein ZO-3 ELISA Kit
 Tight junction protein ZO-3 Recombinant
 Tight junction protein ZO-3 Antibody
Also known as Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3).
ZO3: Interacts with occludin, claudins and ZO-1. Interacts with INADL. Interacts with UBN1. Interacts with FASLG. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Loca
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tion of Human Ortholog: 19p13.3

Cellular Component: nucleus; tight junction

Molecular Function: protein binding
 TJP3 ELISA Kit
 TJP3 Recombinant
 TJP3 Antibody
 ZO3 ELISA Kit
 ZO3 Recombinant
 ZO3 Antibody
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