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TIR domain-containing adapter molecule

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Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Below are the list of possible TIR domain-containing adapter molecule products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TIR domain-containing adapter molecule 1

 TIR domain-containing adapter molecule 1 ELISA Kit
 TIR domain-containing adapter molecule 1 Recombinant
 TIR domain-containing adapter molecule 1 Antibody
Also known as TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta).
TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors resul
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ts in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytosol; endosome membrane

Molecular Function: protein binding; protein kinase binding; signal transducer activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to exogenous dsRNA

Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
 TICAM1 ELISA Kit
 TICAM1 Recombinant
 TICAM1 Antibody
 PRVTIRB ELISA Kit
 PRVTIRB Recombinant
 PRVTIRB Antibody
 TRIF ELISA Kit
 TRIF Recombinant
 TRIF Antibody
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TIR domain-containing adapter molecule 2

 TIR domain-containing adapter molecule 2 ELISA Kit
 TIR domain-containing adapter molecule 2 Recombinant
 TIR domain-containing adapter molecule 2 Antibody
Also known as TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4).
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity wi
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th the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
 TICAM2 ELISA Kit
 TICAM2 Recombinant
 TICAM2 Antibody
 TIRAP3 ELISA Kit
 TIRAP3 Recombinant
 TIRAP3 Antibody
 TIRP ELISA Kit
 TIRP Recombinant
 TIRP Antibody
 TRAM ELISA Kit
 TRAM Recombinant
 TRAM Antibody
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