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TNF receptor-associated factor

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Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).

Below are the list of possible TNF receptor-associated factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TNF receptor-associated factor 1

 TNF receptor-associated factor 1 ELISA Kit
 TNF receptor-associated factor 1 Recombinant
 TNF receptor-associated factor 1 Antibody
TRAF1: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to T
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NFRSF1B/TNFR2. Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3. Interacts with MAP3K14. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Apoptosis

Molecular Function: protein binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor
 Traf1 ELISA Kit
 Traf1 Recombinant
 Traf1 Antibody
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TNF receptor-associated factor 2

 TNF receptor-associated factor 2 ELISA Kit
 TNF receptor-associated factor 2 Recombinant
 TNF receptor-associated factor 2 Antibody
Also known as TNF receptor-associated factor 2 (E3 ubiquitin-protein ligase TRAF2).
TRAF2: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIP
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K1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with BIRC2 and BIRC3 N- terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, DAB2IP, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1- phosphate. Belongs to the TNF receptor-associated factor family. A subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cell cortex; cytoplasm; cytosol; internal side of plasma membrane; lipid raft; protein complex; ubiquitin ligase complex; vesicle membrane

Molecular Function: CD40 receptor binding; enzyme binding; identical protein binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein complex binding; protein kinase binding; protein phosphatase binding; receptor binding; sphingolipid binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; cellular protein complex assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of JNK activity; positive regulation of T cell cytokine production; positive regulation of transcription factor activity; protein autoubiquitination; protein catabolic process; protein complex assembly; protein heterooligomerization; regulation of apoptosis; regulation of immunoglobulin secretion; regulation of JNK cascade; signal transduction; tumor necrosis factor-mediated signaling pathway
 Traf2 ELISA Kit
 Traf2 Recombinant
 Traf2 Antibody
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TNF receptor-associated factor 3

 TNF receptor-associated factor 3 ELISA Kit
 TNF receptor-associated factor 3 Recombinant
 TNF receptor-associated factor 3 Antibody
Also known as TNF receptor-associated factor 3 (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1).
TRAF3: Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of sev
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eral E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N. Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Belongs to the TNF receptor-associated factor family. A subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 14q32.32

Cellular Component: cytosol; internal side of plasma membrane

Molecular Function: protein binding; protein phosphatase binding; signal transducer activity; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of interferon type I production; regulation of cytokine production; regulation of defense response to virus; regulation of interferon-beta production; regulation of proteolysis; signal transduction; toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway

Disease: Herpes Simplex Encephalitis, Susceptibility To, 3
 TRAF3 ELISA Kit
 TRAF3 Recombinant
 TRAF3 Antibody
 CAP1 ELISA Kit
 CAP1 Recombinant
 CAP1 Antibody
 CRAF1 ELISA Kit
 CRAF1 Recombinant
 CRAF1 Antibody
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TNF receptor-associated factor 4

 TNF receptor-associated factor 4 ELISA Kit
 TNF receptor-associated factor 4 Recombinant
 TNF receptor-associated factor 4 Antibody
Also known as TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83).
TRAF4: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal d
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evelopment of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; DNA-binding

Chromosomal Location of Human Ortholog: 17q11-q12

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; identical protein binding; protein binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; WW domain binding

Biological Process: positive regulation of JNK cascade; positive regulation of protein kinase activity; signal transduction
 TRAF4 ELISA Kit
 TRAF4 Recombinant
 TRAF4 Antibody
 CART1 ELISA Kit
 CART1 Recombinant
 CART1 Antibody
 MLN62 ELISA Kit
 MLN62 Recombinant
 MLN62 Antibody
 RNF83 ELISA Kit
 RNF83 Recombinant
 RNF83 Antibody
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TNF receptor-associated factor 5

 TNF receptor-associated factor 5 ELISA Kit
 TNF receptor-associated factor 5 Recombinant
 TNF receptor-associated factor 5 Antibody
TRAF5: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Belongs to the TNF receptor-associated factor family. A subfamily.

Protein type: Adaptor/scaffold; U
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biquitin conjugating system

Cellular Component: centrosome; cytoplasm; cytosol; internal side of plasma membrane

Molecular Function: signal transducer activity; thioesterase binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; positive regulation of cell proliferation; positive regulation of transcription factor activity; signal transduction
 Traf5 ELISA Kit
 Traf5 Recombinant
 Traf5 Antibody
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TNF receptor-associated factor 6

 TNF receptor-associated factor 6 ELISA Kit
 TNF receptor-associated factor 6 Recombinant
 TNF receptor-associated factor 6 Antibody
Also known as TNF receptor-associated factor 6 (E3 ubiquitin-protein ligase TRAF6).
TRAF6: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-
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kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL- 1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with AJUBA. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRAF3IP2. Interacts with LIMD1 (via LIM domains). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Belongs to the TNF receptor-associated factor family. A subfamily.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane; lipid particle; mitochondrion; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function: histone deacetylase binding; identical protein binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein kinase B binding; protein kinase binding; protein N-terminus binding; signal transducer activity; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; activation of protein kinase activity; antigen processing and presentation of exogenous peptide antigen via MHC class II; bone remodeling; bone resorption; cell development; cytokine and chemokine mediated signaling pathway; I-kappaB kinase/NF-kappaB cascade; immune response; JNK cascade; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural tube closure; odontogenesis of dentine-containing teeth; organ morphogenesis; ossification; osteoclast differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of interleukin-2 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein autoubiquitination; protein complex assembly; protein polyubiquitination; protein ubiquitination; regulation of immunoglobulin secretion; signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
 Traf6 ELISA Kit
 Traf6 Recombinant
 Traf6 Antibody
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TNF receptor-associated factor 6-A

 TNF receptor-associated factor 6-A ELISA Kit
 TNF receptor-associated factor 6-A Recombinant
 TNF receptor-associated factor 6-A Antibody
Also known as TNF receptor-associated factor 6-A (E3 ubiquitin-protein ligase TRAF6).
E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction ().
 traf6-a ELISA Kit
 traf6-a Recombinant
 traf6-a Antibody
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TNF receptor-associated factor 6-B

 TNF receptor-associated factor 6-B ELISA Kit
 TNF receptor-associated factor 6-B Recombinant
 TNF receptor-associated factor 6-B Antibody
Also known as TNF receptor-associated factor 6-B (E3 ubiquitin-protein ligase TRAF6).
E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction ().
 traf6-b ELISA Kit
 traf6-b Recombinant
 traf6-b Antibody
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