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Toll/interleukin-1 receptor domain-containing adapter protein

Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF-alpha and interleukin-6 (By similarity).

Below are the list of possible Toll/interleukin-1 receptor domain-containing adapter protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Toll/interleukin-1 receptor domain-containing adapter protein

 Toll/interleukin-1 receptor domain-containing adapter protein ELISA Kit
 Toll/interleukin-1 receptor domain-containing adapter protein Recombinant
 Toll/interleukin-1 receptor domain-containing adapter protein Antibody
Also known as Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein).
TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inf
lammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cytoplasm; endocytic vesicle; intercellular bridge; nucleoplasm; peroxisome; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; cell surface receptor linked signal transduction; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB cascade; myeloid cell differentiation; positive regulation of B cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of innate immune response; positive regulation of interleukin-12 production; positive regulation of interleukin-15 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; regulation of interferon-beta production; regulation of interleukin-15 production; response to bacterium; response to lipopolysaccharide; toll-like receptor 5 signaling pathway
 Tirap ELISA Kit
 Tirap Recombinant
 Tirap Antibody
 Mal ELISA Kit
 Mal Recombinant
 Mal Antibody
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