Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Toll/interleukin-1 receptor domain-containing adapter protein  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • gap junction protein, alpha 3, 46kDa (GJA3) ELISA Kit
 • 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase b... ELISA Kit
 • b2-Microglobulin (HLA-G) Antibody
 • JAG1 siRNA
 • B human blood group antigen IgM Antibody
 • Free Prostate Specific Antigen, fPSA ELISA Kit
 • Procollagen Type I N-Terminal Propeptide (PINP) ELISA Kit
 • H (+)-Cl (-) exchange transporter ClcA (EcolC_3504) Recombinant Protein
 • DOK1 Antibody
 • WNK1 Antibody
 • Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Recombinant Protein
 • ILF2 - NF45 Peptide
 • Mouse Anti-Mouse I-A^b Secondary Antibody
 • B-lymphocyte antigen CD20 (MS4A1) ELISA Kit
 downarrow more ...
separator

Toll/interleukin-1 receptor domain-containing adapter protein

separator
Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF-alpha and interleukin-6 (By similarity).

Below are the list of possible Toll/interleukin-1 receptor domain-containing adapter protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Toll/interleukin-1 receptor domain-containing adapter protein

 Toll/interleukin-1 receptor domain-containing adapter protein ELISA Kit
 Toll/interleukin-1 receptor domain-containing adapter protein Recombinant
 Toll/interleukin-1 receptor domain-containing adapter protein Antibody
Also known as Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein).
TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inf
>>>
lammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: cytoplasm; endocytic vesicle; intercellular bridge; nucleoplasm; peroxisome; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; cell surface receptor linked signal transduction; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB cascade; myeloid cell differentiation; positive regulation of B cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of innate immune response; positive regulation of interleukin-12 production; positive regulation of interleukin-15 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; regulation of interferon-beta production; regulation of interleukin-15 production; response to bacterium; response to lipopolysaccharide; toll-like receptor 5 signaling pathway
 Tirap ELISA Kit
 Tirap Recombinant
 Tirap Antibody
 Mal ELISA Kit
 Mal Recombinant
 Mal Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions