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Toll-like receptor

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Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen .

Below are the list of possible Toll-like receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Toll-like receptor 1

 Toll-like receptor 1 ELISA Kit
 Toll-like receptor 1 Recombinant
 Toll-like receptor 1 Antibody
Also known as Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281).
TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88
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(via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft

Molecular Function: protein heterodimerization activity; transmembrane receptor activity

Biological Process: defense response; defense response to bacterium; detection of triacylated bacterial lipoprotein; microglial cell activation; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to bacterial lipoprotein; toll-like receptor signaling pathway
 Tlr1 ELISA Kit
 Tlr1 Recombinant
 Tlr1 Antibody
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Toll-like receptor 10

 Toll-like receptor 10 ELISA Kit
 Toll-like receptor 10 Recombinant
 Toll-like receptor 10 Antibody
Also known as Toll-like receptor 10 (CD antigen CD290).
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response ().
 TLR10 ELISA Kit
 TLR10 Recombinant
 TLR10 Antibody
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Toll-like receptor 11

 Toll-like receptor 11 ELISA Kit
 Toll-like receptor 11 Recombinant
 Toll-like receptor 11 Antibody
Tlr11: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Biological Process: immune response; response to bacterium
 Tlr11 ELISA Kit
 Tlr11 Recombinant
 Tlr11 Antibody
 Gm287 ELISA Kit
 Gm287 Recombinant
 Gm287 Antibody
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Toll-like receptor 12

 Toll-like receptor 12 ELISA Kit
 Toll-like receptor 12 Recombinant
 Toll-like receptor 12 Antibody
TLR12: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Biological Process: def
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ense response to protozoan; immune response
 Tlr12 ELISA Kit
 Tlr12 Recombinant
 Tlr12 Antibody
 Gm1365 ELISA Kit
 Gm1365 Recombinant
 Gm1365 Antibody
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Toll-like receptor 13

 Toll-like receptor 13 ELISA Kit
 Toll-like receptor 13 Recombinant
 Toll-like receptor 13 Antibody
TLR13: Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequenc
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e on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: cytoplasm; endosome

Molecular Function: double-stranded RNA binding; protein binding; protein homodimerization activity; rRNA binding

Biological Process: innate immune response; MyD88-dependent toll-like receptor signaling pathway; regulation of MAPKKK cascade; response to virus; toll-like receptor 13 signaling pathway
 Tlr13 ELISA Kit
 Tlr13 Recombinant
 Tlr13 Antibody
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Toll-like receptor 2

 Toll-like receptor 2 ELISA Kit
 Toll-like receptor 2 Recombinant
 Toll-like receptor 2 Antibody
Also known as Toll-like receptor 2 (CD antigen CD282).
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory respo
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nse (). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides ().
 TLR2 ELISA Kit
 TLR2 Recombinant
 TLR2 Antibody
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Toll-like receptor 2 type-1

 Toll-like receptor 2 type-1 ELISA Kit
 Toll-like receptor 2 type-1 Recombinant
 Toll-like receptor 2 type-1 Antibody
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).
 TLR2-1 ELISA Kit
 TLR2-1 Recombinant
 TLR2-1 Antibody
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Toll-like receptor 2 type-2

 Toll-like receptor 2 type-2 ELISA Kit
 Toll-like receptor 2 type-2 Recombinant
 Toll-like receptor 2 type-2 Antibody
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).
 TLR2-2 ELISA Kit
 TLR2-2 Recombinant
 TLR2-2 Antibody
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Toll-like receptor 3

 Toll-like receptor 3 ELISA Kit
 Toll-like receptor 3 Recombinant
 Toll-like receptor 3 Antibody
Also known as Toll-like receptor 3 (CD antigen CD283).
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-
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kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response ().
 TLR3 ELISA Kit
 TLR3 Recombinant
 TLR3 Antibody
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Toll-like receptor 4

 Toll-like receptor 4 ELISA Kit
 Toll-like receptor 4 Recombinant
 Toll-like receptor 4 Antibody
Also known as Toll-like receptor 4 (CD antigen CD284).
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:17559944). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmi
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tate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- ().
 TLR4 ELISA Kit
 TLR4 Recombinant
 TLR4 Antibody
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Toll-like receptor 5

 Toll-like receptor 5 ELISA Kit
 Toll-like receptor 5 Recombinant
 Toll-like receptor 5 Antibody
TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with
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a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: integral to plasma membrane; membrane

Molecular Function: interleukin-1 receptor binding; receptor activity

Biological Process: defense response to Gram-negative bacterium; inflammatory response; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; toll-like receptor signaling pathway
 Tlr5 ELISA Kit
 Tlr5 Recombinant
 Tlr5 Antibody
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Toll-like receptor 6

 Toll-like receptor 6 ELISA Kit
 Toll-like receptor 6 Recombinant
 Toll-like receptor 6 Antibody
Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during converg
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ent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
 Toll-6 ELISA Kit
 Toll-6 Recombinant
 Toll-6 Antibody
 Tl-6 ELISA Kit
 Tl-6 Recombinant
 Tl-6 Antibody
 CG7250 ELISA Kit
 CG7250 Recombinant
 CG7250 Antibody
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Toll-like receptor 7

 Toll-like receptor 7 ELISA Kit
 Toll-like receptor 7 Recombinant
 Toll-like receptor 7 Antibody
TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MY
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D88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Cellular Component: cytoplasm; endoplasmic reticulum; endosome; integral to plasma membrane; lysosome; plasma membrane; receptor complex

Molecular Function: double-stranded RNA binding; drug binding; protein binding; receptor activity; single-stranded RNA binding; siRNA binding

Biological Process: defense response to virus; I-kappaB phosphorylation; inflammatory response; microglial cell activation; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; regulation of protein amino acid phosphorylation; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway
 Tlr7 ELISA Kit
 Tlr7 Recombinant
 Tlr7 Antibody
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Toll-like receptor 8

 Toll-like receptor 8 ELISA Kit
 Toll-like receptor 8 Recombinant
 Toll-like receptor 8 Antibody
Also known as Toll-like receptor 8 (CD antigen CD288).
TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor f
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amily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to membrane

Molecular Function: DNA binding; double-stranded RNA binding; RNA binding; single-stranded RNA binding

Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB cascade; immunoglobulin mediated immune response; positive regulation of innate immune response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-8 biosynthetic process; response to virus; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
 TLR8 ELISA Kit
 TLR8 Recombinant
 TLR8 Antibody
 UNQ249/PRO286 ELISA Kit
 UNQ249/PRO286 Recombinant
 UNQ249/PRO286 Antibody
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Toll-like receptor 9

 Toll-like receptor 9 ELISA Kit
 Toll-like receptor 9 Recombinant
 Toll-like receptor 9 Antibody
Also known as Toll-like receptor 9 (CD antigen CD289).
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading
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to NF-kappa-B activation, cytokine secretion and the inflammatory response ().
 TLR9 ELISA Kit
 TLR9 Recombinant
 TLR9 Antibody
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Toll-like receptor Tollo

 Toll-like receptor Tollo ELISA Kit
 Toll-like receptor Tollo Recombinant
 Toll-like receptor Tollo Antibody
Also known as Toll-like receptor Tollo (Toll-like receptor 8).
Toll-related receptor (PubMed:10973475). Probably specific to larval innate immunity (PubMed:22022271). Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP) (PubMed:22022271). Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition (PubMed:25477468). Involved in
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neuron-specific glycosylation (PubMed:12588858, PubMed:17264077). Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway (PubMed:24662564). During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells (PubMed:18000549). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May have a minor role in leg development (PubMed:21158756). May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway.(PubMed:17078066). May also be involved in the Dpp signaling pathway in the eye (PubMed:17078066). Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762).
 Tollo ELISA Kit
 Tollo Recombinant
 Tollo Antibody
 Tl-8 ELISA Kit
 Tl-8 Recombinant
 Tl-8 Antibody
 Toll-8 ELISA Kit
 Toll-8 Recombinant
 Toll-8 Antibody
 CG6890 ELISA Kit
 CG6890 Recombinant
 CG6890 Antibody
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