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TOM1-like protein

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Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).

Below are the list of possible TOM1-like protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TOM1-like protein 1

 TOM1-like protein 1 ELISA Kit
 TOM1-like protein 1 Recombinant
 TOM1-like protein 1 Antibody
Also known as TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1).
Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosi
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s of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: cytoplasm; cytosol; endosome; lysosome

Molecular Function: clathrin binding; protein binding; protein kinase binding; ubiquitin binding

Biological Process: activation of protein kinase activity; negative regulation of mitosis; positive regulation of protein amino acid autophosphorylation; signal transduction
 TOM1L1 ELISA Kit
 TOM1L1 Recombinant
 TOM1L1 Antibody
 SRCASM ELISA Kit
 SRCASM Recombinant
 SRCASM Antibody
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TOM1-like protein 2

 TOM1-like protein 2 ELISA Kit
 TOM1-like protein 2 Recombinant
 TOM1-like protein 2 Antibody
Also known as TOM1-like protein 2 (Target of Myb-like protein 2).
TOM1L2: a protein of unknown function. Contains a VHS and GAT domain. The VHS domain is considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. The GAT domain is responsible for binding of GGA proteins to several members of the ARF. It stabilizes membrane bound ARF1 in its GTP bound state,
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by interfering with GAP proteins.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 17p11.2

Molecular Function: clathrin binding; protein binding; protein kinase binding

Biological Process: negative regulation of mitosis; signal transduction
 TOM1L2 ELISA Kit
 TOM1L2 Recombinant
 TOM1L2 Antibody
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