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Tomoregulin

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May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.

Below are the list of possible Tomoregulin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tomoregulin-1

 Tomoregulin-1 ELISA Kit
 Tomoregulin-1 Recombinant
 Tomoregulin-1 Antibody
Also known as Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain).
TMEFF1: a single-pass type I membrane protein. May inhibit NODAL and BMP signaling during neural patterning. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once
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thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues. Expressed in a variety of cancers cell lines and in myeloma cells. Belongs to the tomoregulin family. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q31
 TMEFF1 ELISA Kit
 TMEFF1 Recombinant
 TMEFF1 Antibody
 C9orf2 ELISA Kit
 C9orf2 Recombinant
 C9orf2 Antibody
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Tomoregulin-2

 Tomoregulin-2 ELISA Kit
 Tomoregulin-2 Recombinant
 Tomoregulin-2 Antibody
Also known as Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains).
TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, tes
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tis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32.3

Biological Process: negative regulation of cell migration; negative regulation of integrin biosynthetic process; negative regulation of stress fiber formation
 TMEFF2 ELISA Kit
 TMEFF2 Recombinant
 TMEFF2 Antibody
 HPP1 ELISA Kit
 HPP1 Recombinant
 HPP1 Antibody
 TENB2 ELISA Kit
 TENB2 Recombinant
 TENB2 Antibody
 TPEF ELISA Kit
 TPEF Recombinant
 TPEF Antibody
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