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TP53-regulating kinase

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Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.

Below are the list of possible TP53-regulating kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TP53-regulating kinase

 TP53-regulating kinase ELISA Kit
 TP53-regulating kinase Recombinant
 TP53-regulating kinase Antibody
Also known as TP53-regulating kinase (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (Nori-2) (p53-related protein kinase).
PRPK: a protein kinase of the "Other" group that phosphorylates 'Ser15' of p53 and may therefore participate in its activation. Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP
>>>
) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Belongs to the protein kinase superfamily.

Protein type: Bud32 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function: p53 binding; protein binding; protein serine/threonine kinase activity

Biological Process: protein amino acid phosphorylation
 TP53RK ELISA Kit
 TP53RK Recombinant
 TP53RK Antibody
 C20orf64 ELISA Kit
 C20orf64 Recombinant
 C20orf64 Antibody
 PRPK ELISA Kit
 PRPK Recombinant
 PRPK Antibody
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