Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow TRAF2 and NCK-interacting protein kinase  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) ELISA Kit
 • VEGF189 Recombinant Protein
 • solute carrier family 4, sodium borate transporter, member 1... ELISA Kit
 • Chlamydia trachomatis Antibody
 • CD41 Antibody
 • Soluble Platelet-Selectin (SP-SELECTIN) ELISA Kit
 • JAGGED2 Antibody
 • Coagulation Factor XI (F11) ELISA Kit
 • Von Willebrand Factor (vWF) Antibody
 • ADAM metallopeptidase domain 33 (ADAM33) ELISA Kit
 • pyrroline-5-carboxylate reductase 1 (PYCR1) ELISA Kit
 • Islet amyloid polypeptide (IAPP) ELISA Kit
 • ALDH18A1 Antibody
 • ADH1B Antibody
 downarrow more ...
separator

TRAF2 and NCK-interacting protein kinase

separator
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Below are the list of possible TRAF2 and NCK-interacting protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

TRAF2 and NCK-interacting protein kinase

 TRAF2 and NCK-interacting protein kinase ELISA Kit
 TRAF2 and NCK-interacting protein kinase Recombinant
 TRAF2 and NCK-interacting protein kinase Antibody
TNIK: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK whic
>>>
h regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: apical plasma membrane; cytoplasm; cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; activation of JNKK activity; cytoskeleton organization and biogenesis; microvillus biogenesis; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite morphogenesis

Disease: Mental Retardation, Autosomal Recessive 54
 TNIK ELISA Kit
 TNIK Recombinant
 TNIK Antibody
 KIAA0551 ELISA Kit
 KIAA0551 Recombinant
 KIAA0551 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions