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Transcription activator

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Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.

Below are the list of possible Transcription activator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Transcription activator BRG1

 Transcription activator BRG1 ELISA Kit
 Transcription activator BRG1 Recombinant
 Transcription activator BRG1 Antibody
Also known as Transcription activator BRG1 (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin.
SMARCA4: a member of the SWI/SNF nucleosome remodeling complex with ATP-dependent DNA helicase activity. SWI/SNF complexes are required for mammalian development and are mutated in ~20% of all human primary tumors. Mutated in 35% (13/37) of NSCLC and 5% (1/19) of SCLC human lung cancer cell lines . A component of the CREST-BRG1 complex,
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a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Belongs to the neural progenitor-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Transcriptional coactivator of nuclear hormone receptors. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription, and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. SMARCA4, in consort with ZEB1, represses the transcription of E-cadherin and promotes the epithelial-to-mesenchymal transisition (EMT). SMARCA4 is required for stem cell maintenance in the mouse intestinal epithelium. Its loss inhibits aberrant Wnt-signalling and prevents tumorigenesis in the mouse small intestine. SMARCA4 mutations are the cause of a familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood. Belongs to the SNF2/RAD54 helicase family. The human protein includes 5 isoforms produced by alternative splicing.

Protein type: Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; membrane; nuclear chromatin; nucleolus; nucleoplasm; nucleus; protein complex; SWI/SNF complex

Molecular Function: androgen receptor binding; DNA-dependent ATPase activity; nucleosomal DNA binding; p53 binding; protein binding; protein N-terminus binding; Tat protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding

Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter, mitotic; negative regulation of transcription, DNA-dependent; nucleosome disassembly; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway

Disease: Mental Retardation, Autosomal Dominant 16; Rhabdoid Tumor Predisposition Syndrome 2
 SMARCA4 ELISA Kit
 SMARCA4 Recombinant
 SMARCA4 Antibody
 BAF190A ELISA Kit
 BAF190A Recombinant
 BAF190A Antibody
 BRG1 ELISA Kit
 BRG1 Recombinant
 BRG1 Antibody
 SNF2B ELISA Kit
 SNF2B Recombinant
 SNF2B Antibody
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Transcription activator GLK1

 Transcription activator GLK1 ELISA Kit
 Transcription activator GLK1 Recombinant
 Transcription activator GLK1 Antibody
Also known as Transcription activator GLK1 (GBF'S PRO-RICH REGION-INTERACTING factor 1) (Golden2-like protein 1) (AtGLK1).
Encodes GLK1, Golden2-like 1, one of a pair of partially redundant nuclear transcription factors that regulate chloroplast development in a cell-autonomous manner. GLK2, Golden2-like 2, is encoded by At5g44190. GLK1 and GLK2 regulate the expression of the photosynthetic apparatus.
 GLK1 ELISA Kit
 GLK1 Recombinant
 GLK1 Antibody
 GPRI1 ELISA Kit
 GPRI1 Recombinant
 GPRI1 Antibody
 At2g20570 ELISA Kit
 At2g20570 Recombinant
 At2g20570 Antibody
 F23N11.11 ELISA Kit
 F23N11.11 Recombinant
 F23N11.11 Antibody
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Transcription activator GLK2

 Transcription activator GLK2 ELISA Kit
 Transcription activator GLK2 Recombinant
 Transcription activator GLK2 Antibody
Also known as Transcription activator GLK2 (GBF'S PRO-RICH REGION-INTERACTING factor 2) (Golden2-like protein 2) (AtGLK2).
Encodes GLK2, Golden2-like 2, one of a pair of partially redundant nuclear transcription factors that regulate chloroplast development in a cell-autonomous manner. GLK1, Golden2-like 1, is encoded by At2g20570. GLK1 and GLK2 regulate the expression of the photosynthetic apparatus.
 GLK2 ELISA Kit
 GLK2 Recombinant
 GLK2 Antibody
 GPRI2 ELISA Kit
 GPRI2 Recombinant
 GPRI2 Antibody
 At5g44190 ELISA Kit
 At5g44190 Recombinant
 At5g44190 Antibody
 MLN1.11 ELISA Kit
 MLN1.11 Recombinant
 MLN1.11 Antibody
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Transcription activator GutR

 Transcription activator GutR ELISA Kit
 Transcription activator GutR Recombinant
 Transcription activator GutR Antibody
Activator of the glucitol dehydrogenase gene (gutB).
 gutR ELISA Kit
 gutR Recombinant
 gutR Antibody
 BSU06140 ELISA Kit
 BSU06140 Recombinant
 BSU06140 Antibody
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Transcription activator MSS11

 Transcription activator MSS11 ELISA Kit
 Transcription activator MSS11 Recombinant
 Transcription activator MSS11 Antibody
Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.
 MSS11 ELISA Kit
 MSS11 Recombinant
 MSS11 Antibody
 CAGL0F07667g ELISA Kit
 CAGL0F07667g Recombinant
 CAGL0F07667g Antibody
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Transcription activator TEC1

 Transcription activator TEC1 ELISA Kit
 Transcription activator TEC1 Recombinant
 Transcription activator TEC1 Antibody
Transcription factor which regulates genes involved in hyphal development, cell ahesion, biofilm development, and virulence. Plays a role in the formation of 'finger' morphology, a unique multicellular morphology of C.albicans induced by carbon dioxide. Regulates gene expression during intestinal colonization. Required for the expression of the secreted aspartyl proteinases SAP4, SAP5, and SAP6; but also of BCR1, PGA4, and CDC24. Moreover, a positive feedback loop between CDC24 and TEC1 contributes to an increase in active CDC42 at the tip of the germ tube which is important for hyphae formati
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on. Regulates also the pheromone response of the white cell phenotype.
 TEC1 ELISA Kit
 TEC1 Recombinant
 TEC1 Antibody
 CaO19.13329 ELISA Kit
 CaO19.13329 Recombinant
 CaO19.13329 Antibody
 CaO19.5908 ELISA Kit
 CaO19.5908 Recombinant
 CaO19.5908 Antibody
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Proteins Root Name Listing
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