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Transcription fator

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Transcription factor that regulates the gene cluster that mediates the biosynthesis of ML-273B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase .

Below are the list of possible Transcription fator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Transcription fator mlcR

 Transcription fator mlcR ELISA Kit
 Transcription fator mlcR Recombinant
 Transcription fator mlcR Antibody
Also known as Transcription fator mlcR (Compactin biosynthesis protein H).
Transcription factor that regulates the gene cluster that mediates the biosynthesis of ML-273B, also known as compactin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803, PubMed:12242508, PubMed:12436257). Binds to the consensus-binding motif 5'-WCGG-N(6)-TCGG-3' of target genes (Pub
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Med:18667169).
 mlcR ELISA Kit
 mlcR Recombinant
 mlcR Antibody
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Transcription fator mokH

 Transcription fator mokH ELISA Kit
 Transcription fator mokH Recombinant
 Transcription fator mokH Antibody
Also known as Transcription fator mokH (Monacolin K biosynthesis protein H).
Transcription factor that regulates the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535, PubMed:19693441, PubMed:19968298). Monakolin K biosynthesis is performed in two stages (PubMed:19693441).
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The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441). HMG-CoA reductase mokG may act as a down-regulator of monacolin K production (PubMed:18578535).
 mokH ELISA Kit
 mokH Recombinant
 mokH Antibody
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