Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Transcription intermediary factor  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • YAP (Phospho-Ser127) Antibody
 • CD3 zeta (Phospho-Tyr142) Antibody
 • POTE8 Antibody
 • OR7E5P Antibody
 • ZNF23 Antibody
 • Acid Sphingomyelinase (ASM) ELISA Kit
 • Fumarase-Fumarate Hydratase ELISA Kit
 • Angiopoietin Like Protein 1 (ANGPTL1) ELISA Kit
 • Galanin Receptor 1 (GALR1) ELISA Kit
 • Myelin Associated Glycoprotein (MAG) ELISA Kit
 • Soluble Liver Antigen (SLA) ELISA Kit
 • Decorin (DCN) ELISA Kit
 • Angiostatin ELISA Kit
 • Calprotectin (CP) ELISA Kit
 downarrow more ...
separator

Transcription intermediary factor

separator
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Below are the list of possible Transcription intermediary factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Transcription intermediary factor 1-alpha

 Transcription intermediary factor 1-alpha ELISA Kit
 Transcription intermediary factor 1-alpha Recombinant
 Transcription intermediary factor 1-alpha Antibody
Also known as Transcription intermediary factor 1-alpha (TIF1-alpha) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24).
TRIM24: an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphory
>>>
lation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described.

Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Tumor suppressor; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 7q32-q34

Cellular Component: cytosol; nucleus

Molecular Function: chromatin binding; estrogen response element binding; methylated histone residue binding; p53 binding; protein binding; protein-tyrosine kinase activity; receptor binding; transcription coactivator activity; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: protein catabolic process; protein ubiquitination; regulation of apoptosis; regulation of protein stability; transcription from RNA polymerase II promoter

Disease: Thyroid Carcinoma, Papillary
 TRIM24 ELISA Kit
 TRIM24 Recombinant
 TRIM24 Antibody
 RNF82 ELISA Kit
 RNF82 Recombinant
 RNF82 Antibody
 TIF1 ELISA Kit
 TIF1 Recombinant
 TIF1 Antibody
 TIF1A ELISA Kit
 TIF1A Recombinant
 TIF1A Antibody
Table BarTOPTable Bar
 

Transcription intermediary factor 1-beta

 Transcription intermediary factor 1-beta ELISA Kit
 Transcription intermediary factor 1-beta Recombinant
 Transcription intermediary factor 1-beta Antibody
Also known as Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (KRAB-A-interacting protein) (KRIP-1) (Tripartite motif-containing protein 28).
TIF1B: an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin r
>>>
egions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

Protein type: ATYPICAL group; EC 6.3.2.-; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: chromatin; nuclear heterochromatin; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; protein binding; protein kinase activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: convergent extension involved in axis elongation; DNA methylation during embryonic development; DNA repair; embryo implantation; epithelial to mesenchymal transition; in utero embryonic development; innate immune response; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of DNA binding; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein oligomerization; protein sumoylation; Ras protein signal transduction
 Trim28 ELISA Kit
 Trim28 Recombinant
 Trim28 Antibody
 Kap1 ELISA Kit
 Kap1 Recombinant
 Kap1 Antibody
 Krip1 ELISA Kit
 Krip1 Recombinant
 Krip1 Antibody
 Tif1b ELISA Kit
 Tif1b Recombinant
 Tif1b Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions