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Transferrin receptor protein

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Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).

Below are the list of possible Transferrin receptor protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Transferrin receptor protein 1

 Transferrin receptor protein 1 ELISA Kit
 Transferrin receptor protein 1 Recombinant
 Transferrin receptor protein 1 Antibody
Also known as Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr).
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotr
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ansferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system ().
 TFRC ELISA Kit
 TFRC Recombinant
 TFRC Antibody
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Transferrin receptor protein 2

 Transferrin receptor protein 2 ELISA Kit
 Transferrin receptor protein 2 Recombinant
 Transferrin receptor protein 2 Antibody
Also known as Transferrin receptor protein 2 (TfR2).
TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable f
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rom that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: cytoplasmic vesicle; external side of plasma membrane; integral to membrane; integral to plasma membrane

Molecular Function: glycoprotein binding; transferrin receptor activity

Biological Process: cellular iron ion homeostasis; iron ion homeostasis; positive regulation of endocytosis; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to iron ion; transferrin transport
 Tfr2 ELISA Kit
 Tfr2 Recombinant
 Tfr2 Antibody
 Trfr2 ELISA Kit
 Trfr2 Recombinant
 Trfr2 Antibody
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