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Transient receptor potential cation channel subfamily

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Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Is also activated by menthol (in vitro) (By similarity). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.

Below are the list of possible Transient receptor potential cation channel subfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Transient receptor potential cation channel subfamily A member 1

 Transient receptor potential cation channel subfamily A member 1 ELISA Kit
 Transient receptor potential cation channel subfamily A member 1 Recombinant
 Transient receptor potential cation channel subfamily A member 1 Antibody
Also known as Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritan
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ts, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; axon; integral to membrane; integral to plasma membrane; stereocilium bundle

Molecular Function: calcium channel activity; calcium-release channel activity; channel activity; ion channel activity; protein binding; voltage-gated calcium channel activity

Biological Process: calcium ion transport; cell surface receptor linked signal transduction; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; protein homotetramerization; response to cold; response to drug; response to hydrogen peroxide; response to organic cyclic substance; response to organic substance; response to pain; sensory perception of pain; signal transduction; thermoception; urinary bladder smooth muscle contraction
 Trpa1 ELISA Kit
 Trpa1 Recombinant
 Trpa1 Antibody
 Anktm1 ELISA Kit
 Anktm1 Recombinant
 Anktm1 Antibody
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Transient receptor potential cation channel subfamily A member 1 homolog

 Transient receptor potential cation channel subfamily A member 1 homolog ELISA Kit
 Transient receptor potential cation channel subfamily A member 1 homolog Recombinant
 Transient receptor potential cation channel subfamily A member 1 homolog Antibody
Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.
 trpa-1 ELISA Kit
 trpa-1 Recombinant
 trpa-1 Antibody
 C29E6.2 ELISA Kit
 C29E6.2 Recombinant
 C29E6.2 Antibody
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Transient receptor potential cation channel subfamily M member 1

 Transient receptor potential cation channel subfamily M member 1 ELISA Kit
 Transient receptor potential cation channel subfamily M member 1 Recombinant
 Transient receptor potential cation channel subfamily M member 1 Antibody
Also known as Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1).
TRPM1: a transient receptor potential (TRP) ion channel. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Its expression is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chrom
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osomal Location of Human Ortholog: 15q13.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: calcium channel activity

Biological Process: metabotropic glutamate receptor signaling pathway; transport; visual perception

Disease: Night Blindness, Congenital Stationary, Type 1c
 TRPM1 ELISA Kit
 TRPM1 Recombinant
 TRPM1 Antibody
 LTRPC1 ELISA Kit
 LTRPC1 Recombinant
 LTRPC1 Antibody
 MLSN ELISA Kit
 MLSN Recombinant
 MLSN Antibody
 MLSN1 ELISA Kit
 MLSN1 Recombinant
 MLSN1 Antibody
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Transient receptor potential cation channel subfamily M member 2

 Transient receptor potential cation channel subfamily M member 2 ELISA Kit
 Transient receptor potential cation channel subfamily M member 2 Recombinant
 Transient receptor potential cation channel subfamily M member 2 Antibody
Nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels (PubMed:16651700, PubMed:16260005, PubMed:11804595, PubMed:16601673, PubMed:19454650). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (). Also contri
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butes to Ca2+ release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca2+ levels (Probable). Besides, mediates the release of lysosomal Zn2+ stores in response to reactive oxygen species, leading to increased cytosolic Zn2+ levels (PubMed:25562606). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD+) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:16260005, PubMed:16601673, PubMed:25562606). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca2+ levels (PubMed:16601673). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca2+ levels (). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca2+ and Zn2+ levels (). Confers susceptibility to cell death following oxidative stress (PubMed:16651700, PubMed:11804595, PubMed:19454650, PubMed:25562606).
 Trpm2 ELISA Kit
 Trpm2 Recombinant
 Trpm2 Antibody
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Transient receptor potential cation channel subfamily M member 3

 Transient receptor potential cation channel subfamily M member 3 ELISA Kit
 Transient receptor potential cation channel subfamily M member 3 Recombinant
 Transient receptor potential cation channel subfamily M member 3 Antibody
Also known as Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2).
TRPM3: a transient receptor potential (TRP) ion channel. Mediates constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by calcium store depletion and muscarinic receptor activation. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Ten alternatively spliced isoforms hav
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e been described.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: plasma membrane

Molecular Function: calcium channel activity; cation channel activity

Biological Process: cation transport
 TRPM3 ELISA Kit
 TRPM3 Recombinant
 TRPM3 Antibody
 KIAA1616 ELISA Kit
 KIAA1616 Recombinant
 KIAA1616 Antibody
 LTRPC3 ELISA Kit
 LTRPC3 Recombinant
 LTRPC3 Antibody
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Transient receptor potential cation channel subfamily M member 4

 Transient receptor potential cation channel subfamily M member 4 ELISA Kit
 Transient receptor potential cation channel subfamily M member 4 Recombinant
 Transient receptor potential cation channel subfamily M member 4 Antibody
Also known as Transient receptor potential cation channel subfamily M member 4 (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4).
TRPM4: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport
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of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B). It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrioventricular block causing syncope and sudden death. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell soma; cytosol; endoplasmic reticulum; Golgi apparatus; integral to membrane; nucleoplasm; plasma membrane

Molecular Function: calcium activated cation channel activity; calcium channel activity; voltage-gated ion channel activity

Biological Process: calcium ion transport; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; negative regulation of bone mineralization; negative regulation of osteoblast differentiation; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of heart rate; positive regulation of vasoconstriction; protein sumoylation; regulation of membrane potential; regulation of T cell cytokine production
 Trpm4 ELISA Kit
 Trpm4 Recombinant
 Trpm4 Antibody
 Ltrpc4 ELISA Kit
 Ltrpc4 Recombinant
 Ltrpc4 Antibody
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Transient receptor potential cation channel subfamily M member 5

 Transient receptor potential cation channel subfamily M member 5 ELISA Kit
 Transient receptor potential cation channel subfamily M member 5 Recombinant
 Transient receptor potential cation channel subfamily M member 5 Antibody
Also known as Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein).
TRPM5: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and
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displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell soma; dendrite; integral to membrane

Molecular Function: calcium activated cation channel activity; potassium channel activity; sodium channel activity
 Trpm5 ELISA Kit
 Trpm5 Recombinant
 Trpm5 Antibody
 Ltrpc5 ELISA Kit
 Ltrpc5 Recombinant
 Ltrpc5 Antibody
 Mtr1 ELISA Kit
 Mtr1 Recombinant
 Mtr1 Antibody
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Transient receptor potential cation channel subfamily M member 6

 Transient receptor potential cation channel subfamily M member 6 ELISA Kit
 Transient receptor potential cation channel subfamily M member 6 Recombinant
 Transient receptor potential cation channel subfamily M member 6 Antibody
Also known as Transient receptor potential cation channel subfamily M member 6 (Channel kinase 2) (Melastatin-related TRP cation channel 6).
ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in
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the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.

Protein type: ATYPICAL group; Alpha family; ChaK subfamily; Channel, cation; EC 2.7.11.1; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, atypical

Cellular Component: apical plasma membrane; brush border membrane

Molecular Function: cation channel activity

Biological Process: metal ion transport; response to toxin
 Trpm6 ELISA Kit
 Trpm6 Recombinant
 Trpm6 Antibody
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Transient receptor potential cation channel subfamily M member 7

 Transient receptor potential cation channel subfamily M member 7 ELISA Kit
 Transient receptor potential cation channel subfamily M member 7 Recombinant
 Transient receptor potential cation channel subfamily M member 7 Antibody
Also known as Transient receptor potential cation channel subfamily M member 7 (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7).
ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus w
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here it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein.

Protein type: ATYPICAL group; Alpha family; ChaK subfamily; Channel, cation; EC 2.7.11.1; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, atypical

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: plasma membrane

Molecular Function: calcium channel activity

Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1
 TRPM7 ELISA Kit
 TRPM7 Recombinant
 TRPM7 Antibody
 CHAK1 ELISA Kit
 CHAK1 Recombinant
 CHAK1 Antibody
 LTRPC7 ELISA Kit
 LTRPC7 Recombinant
 LTRPC7 Antibody
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Transient receptor potential cation channel subfamily M member 8

 Transient receptor potential cation channel subfamily M member 8 ELISA Kit
 Transient receptor potential cation channel subfamily M member 8 Recombinant
 Transient receptor potential cation channel subfamily M member 8 Antibody
Also known as Transient receptor potential cation channel subfamily M member 8 (Cold menthol receptor 1).
TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Per
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meable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: external side of plasma membrane; membrane; plasma membrane

Molecular Function: calcium channel activity; ion channel activity; protein homodimerization activity

Biological Process: calcium ion transport; cellular calcium ion homeostasis; protein homotetramerization; response to cold; response to temperature stimulus; thermoception
 Trpm8 ELISA Kit
 Trpm8 Recombinant
 Trpm8 Antibody
 Cmr1 ELISA Kit
 Cmr1 Recombinant
 Cmr1 Antibody
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Transient receptor potential cation channel subfamily V member 1

 Transient receptor potential cation channel subfamily V member 1 ELISA Kit
 Transient receptor potential cation channel subfamily V member 1 Recombinant
 Transient receptor potential cation channel subfamily V member 1 Antibody
Also known as Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).
TRPV1: a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it function
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s as a transducer of painful thermal stimuli in vivo.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function: ATP binding; calcium channel activity; calcium-release channel activity; excitatory extracellular ligand-gated ion channel activity; extracellular ligand-gated ion channel activity; phosphoinositide binding; phosphoprotein binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; chemosensory behavior; protein homotetramerization; thermoception; transport
 TRPV1 ELISA Kit
 TRPV1 Recombinant
 TRPV1 Antibody
 VR1 ELISA Kit
 VR1 Recombinant
 VR1 Antibody
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Transient receptor potential cation channel subfamily V member 2

 Transient receptor potential cation channel subfamily V member 2 ELISA Kit
 Transient receptor potential cation channel subfamily V member 2 Recombinant
 Transient receptor potential cation channel subfamily V member 2 Antibody
Also known as Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Growth factor-regulated calcium channel) (GRC) (Osm-9-like TRP channel 2) (OTRPC2).
TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Acti
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vated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: axon; cell surface; cytoplasm; endomembrane system; integral to plasma membrane; intracellular; lamellipodium; plasma membrane

Molecular Function: calcium channel activity; cation channel activity

Biological Process: apoptosis; negative regulation of cell proliferation; positive regulation of axon extension; response to heat; response to temperature stimulus
 Trpv2 ELISA Kit
 Trpv2 Recombinant
 Trpv2 Antibody
 Grc ELISA Kit
 Grc Recombinant
 Grc Antibody
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Transient receptor potential cation channel subfamily V member 3

 Transient receptor potential cation channel subfamily V member 3 ELISA Kit
 Transient receptor potential cation channel subfamily V member 3 Recombinant
 Transient receptor potential cation channel subfamily V member 3 Antibody
Also known as Transient receptor potential cation channel subfamily V member 3 (TrpV3).
TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate i
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ts activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane; membrane; receptor complex

Molecular Function: calcium channel activity; cation channel activity; ion channel activity

Biological Process: negative regulation of hair cycle; response to temperature stimulus
 Trpv3 ELISA Kit
 Trpv3 Recombinant
 Trpv3 Antibody
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Transient receptor potential cation channel subfamily V member 4

 Transient receptor potential cation channel subfamily V member 4 ELISA Kit
 Transient receptor potential cation channel subfamily V member 4 Recombinant
 Transient receptor potential cation channel subfamily V member 4 Antibody
Also known as Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC).
TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Incr
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ease of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: adherens junction; cell surface; cilium; cortical actin cytoskeleton; cytoplasmic microtubule; cytoplasmic vesicle; filopodium; focal adhesion; growth cone; integral to plasma membrane; lamellipodium; plasma membrane

Molecular Function: actin binding; actin filament binding; alpha-tubulin binding; beta-tubulin binding; calcium channel activity; calmodulin binding; cation channel activity; microtubule binding; osmosensor activity; protein binding; protein kinase binding; protein kinase C binding; SH2 domain binding; stretch-activated, cation-selective, calcium channel activity

Biological Process: actin cytoskeleton reorganization; actin filament organization; calcium ion transport; cellular calcium ion homeostasis; cortical microtubule organization and biogenesis; diet induced thermogenesis; elevation of cytosolic calcium ion concentration; glucose homeostasis; hyperosmotic salinity response; hypotonic response; intercellular junction assembly; microtubule polymerization; multicellular organismal water homeostasis; negative regulation of transcription from RNA polymerase II promoter; osmosensory signaling pathway; positive regulation of inflammatory response; positive regulation of JNK cascade; positive regulation of microtubule depolymerization; positive regulation of vascular permeability; regulation of response to osmotic stress; response to insulin stimulus; response to lipopolysaccharide; response to osmotic stress; vasopressin secretion
 Trpv4 ELISA Kit
 Trpv4 Recombinant
 Trpv4 Antibody
 Trp12 ELISA Kit
 Trp12 Recombinant
 Trp12 Antibody
 Vrl2 ELISA Kit
 Vrl2 Recombinant
 Vrl2 Antibody
 Vroac ELISA Kit
 Vroac Recombinant
 Vroac Antibody
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Transient receptor potential cation channel subfamily V member 5

 Transient receptor potential cation channel subfamily V member 5 ELISA Kit
 Transient receptor potential cation channel subfamily V member 5 Recombinant
 Transient receptor potential cation channel subfamily V member 5 Antibody
Also known as Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3).
TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level an
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d the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: calcium channel activity; protein binding

Biological Process: calcium ion homeostasis; calcium ion transport; protein tetramerization
 TRPV5 ELISA Kit
 TRPV5 Recombinant
 TRPV5 Antibody
 ECAC1 ELISA Kit
 ECAC1 Recombinant
 ECAC1 Antibody
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Transient receptor potential cation channel subfamily V member 6

 Transient receptor potential cation channel subfamily V member 6 ELISA Kit
 Transient receptor potential cation channel subfamily V member 6 Recombinant
 Transient receptor potential cation channel subfamily V member 6 Antibody
Also known as Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2).
TRPV6: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calci
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um store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: calcium activated cation channel activity; calcium channel activity; calmodulin binding

Biological Process: calcium ion homeostasis; calcium ion transport; protein homotetramerization; response to calcium ion
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