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Tribbles

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Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase .

Below are the list of possible Tribbles products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tribbles homolog 1

 Tribbles homolog 1 ELISA Kit
 Tribbles homolog 1 Recombinant
 Tribbles homolog 1 Antibody
Also known as Tribbles homolog 1 (TRB-1).
TRB1: Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family

Cellular Componen
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t: cytoplasm; nucleus

Molecular Function: ATP binding; mitogen-activated protein kinase kinase binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity

Biological Process: JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neutrophil differentiation; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; negative regulation of transcription factor activity; positive regulation of eosinophil differentiation; positive regulation of macrophage differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity; protein amino acid phosphorylation; regulation of catalytic activity; regulation of MAP kinase activity; response to lipopolysaccharide
 Trib1 ELISA Kit
 Trib1 Recombinant
 Trib1 Antibody
 Trb1 ELISA Kit
 Trb1 Recombinant
 Trb1 Antibody
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Tribbles homolog 2

 Tribbles homolog 2 ELISA Kit
 Tribbles homolog 2 Recombinant
 Tribbles homolog 2 Antibody
Also known as Tribbles homolog 2 (TRB-2).
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity ().
 TRIB2 ELISA Kit
 TRIB2 Recombinant
 TRIB2 Antibody
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Tribbles homolog 3

 Tribbles homolog 3 ELISA Kit
 Tribbles homolog 3 Recombinant
 Tribbles homolog 3 Antibody
Also known as Tribbles homolog 3 (TRB-3).
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional acti
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vation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity (). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (). Can inhibit APOBEC3A editing of nuclear DNA ().
 TRIB3 ELISA Kit
 TRIB3 Recombinant
 TRIB3 Antibody
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