| tRNA (cytosine(34)-C(5))-methyltransferase ELISA Kit|
tRNA (cytosine(34)-C(5))-methyltransferase Recombinant
tRNA (cytosine(34)-C(5))-methyltransferase Antibody
|Also known as tRNA (cytosine(34)-C(5))-methyltransferase (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2). |
NSUN2: an RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Interacts with NPM1 and NCL during interphase. Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA. Defects in NSUN2 are the cause of mental retardation autosomal recessive type 5 (MRT5), a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Two human isoforms produced by alternative splicing.
Protein type: EC 18.104.22.168; Methyltransferase; Nucleolus; RNA-binding
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: tRNA (cytosine-5-)-methyltransferase activity; tRNA binding
Biological Process: meiotic cell cycle checkpoint; spermatid development; tRNA methylation
| Nsun2 ELISA Kit|
| D13Wsu123e ELISA Kit|
| Misu ELISA Kit|