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tRNA-splicing endonuclease

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Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).

Below are the list of possible tRNA-splicing endonuclease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

tRNA-splicing endonuclease

 tRNA-splicing endonuclease ELISA Kit
 tRNA-splicing endonuclease Recombinant
 tRNA-splicing endonuclease Antibody
Also known as tRNA-splicing endonuclease (tRNA-intron endonuclease).
Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp ().
 endA ELISA Kit
 endA Recombinant
 endA Antibody
 MA_3624 ELISA Kit
 MA_3624 Recombinant
 MA_3624 Antibody
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tRNA-splicing endonuclease subunit Sen15

 tRNA-splicing endonuclease subunit Sen15 ELISA Kit
 tRNA-splicing endonuclease subunit Sen15 Recombinant
 tRNA-splicing endonuclease subunit Sen15 Antibody
Also known as tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15).
TSEN15: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice site
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s an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Belongs to the SEN15 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm

Biological Process: tRNA splicing

Disease: Pontocerebellar Hypoplasia, Type 2f
 TSEN15 ELISA Kit
 TSEN15 Recombinant
 TSEN15 Antibody
 C1orf19 ELISA Kit
 C1orf19 Recombinant
 C1orf19 Antibody
 SEN15 ELISA Kit
 SEN15 Recombinant
 SEN15 Antibody
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tRNA-splicing endonuclease subunit SEN2

 tRNA-splicing endonuclease subunit SEN2 ELISA Kit
 tRNA-splicing endonuclease subunit SEN2 Recombinant
 tRNA-splicing endonuclease subunit SEN2 Antibody
Also known as tRNA-splicing endonuclease subunit SEN2 (Splicing endonuclease protein 2) (tRNA-intron endonuclease SEN2).
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, p
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lacing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage.
 SEN2 ELISA Kit
 SEN2 Recombinant
 SEN2 Antibody
 YLR105C ELISA Kit
 YLR105C Recombinant
 YLR105C Antibody
 L8004.12 ELISA Kit
 L8004.12 Recombinant
 L8004.12 Antibody
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tRNA-splicing endonuclease subunit Sen2-1

 tRNA-splicing endonuclease subunit Sen2-1 ELISA Kit
 tRNA-splicing endonuclease subunit Sen2-1 Recombinant
 tRNA-splicing endonuclease subunit Sen2-1 Antibody
Also known as tRNA-splicing endonuclease subunit Sen2-1 (tRNA-intron endonuclease Sen2-1) (AtSen1).
Encodes a catalytic subunit of tRNA splicing endonuclease.
 SEN1 ELISA Kit
 SEN1 Recombinant
 SEN1 Antibody
 At3g45590 ELISA Kit
 At3g45590 Recombinant
 At3g45590 Antibody
 F9K21.170 ELISA Kit
 F9K21.170 Recombinant
 F9K21.170 Antibody
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tRNA-splicing endonuclease subunit Sen2-2

 tRNA-splicing endonuclease subunit Sen2-2 ELISA Kit
 tRNA-splicing endonuclease subunit Sen2-2 Recombinant
 tRNA-splicing endonuclease subunit Sen2-2 Antibody
Also known as tRNA-splicing endonuclease subunit Sen2-2 (tRNA-intron endonuclease Sen2-2) (AtSen2).
putative subunit of tRNA splicing endonuclease
 SEN2 ELISA Kit
 SEN2 Recombinant
 SEN2 Antibody
 At5g60230 ELISA Kit
 At5g60230 Recombinant
 At5g60230 Antibody
 F15L12.18 ELISA Kit
 F15L12.18 Recombinant
 F15L12.18 Antibody
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tRNA-splicing endonuclease subunit Sen34

 tRNA-splicing endonuclease subunit Sen34 ELISA Kit
 tRNA-splicing endonuclease subunit Sen34 Recombinant
 tRNA-splicing endonuclease subunit Sen34 Antibody
Also known as tRNA-splicing endonuclease subunit Sen34 (Leukocyte receptor cluster member 5 homolog) (tRNA-intron endonuclease Sen34).
TSEN34: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the sa
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me site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'- end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Defects in TSEN34 are the cause of pontocerebellar hypoplasia type 2C (PCH2C). Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea, epilepsy, and normal spinal cord findings. Belongs to the tRNA-intron endonuclease family.

Protein type: EC 4.6.1.16; Nucleolus; Ribonuclease

Cellular Component: nucleus

Molecular Function: protein binding; tRNA-intron endonuclease activity

Biological Process: tRNA-type intron splice site recognition and cleavage
 Tsen34 ELISA Kit
 Tsen34 Recombinant
 Tsen34 Antibody
 Leng5 ELISA Kit
 Leng5 Recombinant
 Leng5 Antibody
 Sen34 ELISA Kit
 Sen34 Recombinant
 Sen34 Antibody
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tRNA-splicing endonuclease subunit Sen54

 tRNA-splicing endonuclease subunit Sen54 ELISA Kit
 tRNA-splicing endonuclease subunit Sen54 Recombinant
 tRNA-splicing endonuclease subunit Sen54 Antibody
Also known as tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54).
TSEN54: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-mole
>>>
cules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Defects in TSEN54 are the cause of pontocerebellar hypoplasia type 4 (PCH4). Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. PCH4 is characterized by severe course and early lethality. Defects in TSEN54 are the cause of pontocerebellar hypoplasia type 2A (PCH2A). Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea, epilepsy, and normal spinal cord findings. Belongs to the SEN54 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: nucleoplasm; tRNA-intron endonuclease complex

Molecular Function: protein binding; tRNA-intron endonuclease activity

Biological Process: tRNA splicing; tRNA-type intron splice site recognition and cleavage

Disease: Pontocerebellar Hypoplasia, Type 2a; Pontocerebellar Hypoplasia, Type 4
 TSEN54 ELISA Kit
 TSEN54 Recombinant
 TSEN54 Antibody
 SEN54 ELISA Kit
 SEN54 Recombinant
 SEN54 Antibody
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