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Tubby-related protein

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Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Below are the list of possible Tubby-related protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tubby-related protein 1

 Tubby-related protein 1 ELISA Kit
 Tubby-related protein 1 Recombinant
 Tubby-related protein 1 Antibody
Also known as Tubby-related protein 1 (Tubby-like protein 1).
TULP1: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidyli
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nositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Defects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14 inheritance is autosomal recessive. Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15). LCA15 is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the TUB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: cell projection; cytosol; extracellular region; nerve terminal; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; synapse

Molecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding

Biological Process: dendrite development; detection of light stimulus involved in visual perception; eye photoreceptor cell development; phagocytosis, recognition; photoreceptor cell maintenance; positive regulation of phagocytosis; retina development in camera-type eye; retinal homeostasis; vesicle-mediated transport
 Tulp1 ELISA Kit
 Tulp1 Recombinant
 Tulp1 Antibody
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Tubby-related protein 2

 Tubby-related protein 2 ELISA Kit
 Tubby-related protein 2 Recombinant
 Tubby-related protein 2 Antibody
Also known as Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2).
TULP2: TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided b
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y RefSeq, Jul 2008]

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cilium

Molecular Function: phosphoinositide binding; protein complex binding

Biological Process: visual perception
 TULP2 ELISA Kit
 TULP2 Recombinant
 TULP2 Antibody
 TUBL2 ELISA Kit
 TUBL2 Recombinant
 TUBL2 Antibody
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Tubby-related protein 3

 Tubby-related protein 3 ELISA Kit
 Tubby-related protein 3 Recombinant
 Tubby-related protein 3 Antibody
Also known as Tubby-related protein 3 (Tubby-like protein 3).
TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cilium; nucleolus; nucleus; plasma membr
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ane

Molecular Function: enzyme binding; phosphoinositide binding; protein binding; protein complex binding

Biological Process: negative regulation of smoothened signaling pathway; regulation of G-protein coupled receptor protein signaling pathway
 TULP3 ELISA Kit
 TULP3 Recombinant
 TULP3 Antibody
 TUBL3 ELISA Kit
 TUBL3 Recombinant
 TUBL3 Antibody
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Tubby-related protein 4

 Tubby-related protein 4 ELISA Kit
 Tubby-related protein 4 Recombinant
 Tubby-related protein 4 Antibody
Also known as Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4).
TULP4: a member of the Tubby-like proteins (TULPs) family, putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. Two alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6q25-q26

Cellular Component: cilium; cytoplasm

Molecular Function: phosphoinositide binding
 TULP4 ELISA Kit
 TULP4 Recombinant
 TULP4 Antibody
 KIAA1397 ELISA Kit
 KIAA1397 Recombinant
 KIAA1397 Antibody
 TUBL4 ELISA Kit
 TUBL4 Recombinant
 TUBL4 Antibody
 TUSP ELISA Kit
 TUSP Recombinant
 TUSP Antibody
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Proteins Root Name Listing
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