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Tumor necrosis factor ligand superfamily

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Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Below are the list of possible Tumor necrosis factor ligand superfamily products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tumor necrosis factor ligand superfamily member 10

 Tumor necrosis factor ligand superfamily member 10 ELISA Kit
 Tumor necrosis factor ligand superfamily member 10 Recombinant
 Tumor necrosis factor ligand superfamily member 10 Antibody
Also known as Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253).
TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isofo
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rms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: extracellular region; integral to plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: caspase activation; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction
 TNFSF10 ELISA Kit
 TNFSF10 Recombinant
 TNFSF10 Antibody
 APO2L ELISA Kit
 APO2L Recombinant
 APO2L Antibody
 TRAIL ELISA Kit
 TRAIL Recombinant
 TRAIL Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 11

 Tumor necrosis factor ligand superfamily member 11 ELISA Kit
 Tumor necrosis factor ligand superfamily member 11 Recombinant
 Tumor necrosis factor ligand superfamily member 11 Antibody
Also known as Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254).
TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of th
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e T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: extracellular region; plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding

Biological Process: activation of NF-kappaB transcription factor; calcium-mediated signaling; cytokine and chemokine mediated signaling pathway; monocyte chemotaxis; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway

Disease: Osteopetrosis, Autosomal Recessive 2
 TNFSF11 ELISA Kit
 TNFSF11 Recombinant
 TNFSF11 Antibody
 OPGL ELISA Kit
 OPGL Recombinant
 OPGL Antibody
 RANKL ELISA Kit
 RANKL Recombinant
 RANKL Antibody
 TRANCE ELISA Kit
 TRANCE Recombinant
 TRANCE Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 12

 Tumor necrosis factor ligand superfamily member 12 ELISA Kit
 Tumor necrosis factor ligand superfamily member 12 Recombinant
 Tumor necrosis factor ligand superfamily member 12 Antibody
Also known as Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK).
TNFSF12: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appen
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dix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: extracellular region; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: apoptosis; endothelial cell migration; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of protein catabolic process; signal transduction; tumor necrosis factor-mediated signaling pathway
 TNFSF12 ELISA Kit
 TNFSF12 Recombinant
 TNFSF12 Antibody
 APO3L ELISA Kit
 APO3L Recombinant
 APO3L Antibody
 DR3LG ELISA Kit
 DR3LG Recombinant
 DR3LG Antibody
 UNQ181/PRO207 ELISA Kit
 UNQ181/PRO207 Recombinant
 UNQ181/PRO207 Antibody
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Tumor necrosis factor ligand superfamily member 13

 Tumor necrosis factor ligand superfamily member 13 ELISA Kit
 Tumor necrosis factor ligand superfamily member 13 Recombinant
 Tumor necrosis factor ligand superfamily member 13 Antibody
Also known as Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (CD antigen CD256).
TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human p
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rotein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: cytoplasm; external side of plasma membrane

Biological Process: immunoglobulin mediated immune response; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of isotype switching to IgA isotypes; regulation of immune response
 Tnfsf13 ELISA Kit
 Tnfsf13 Recombinant
 Tnfsf13 Antibody
 April ELISA Kit
 April Recombinant
 April Antibody
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Tumor necrosis factor ligand superfamily member 13B

 Tumor necrosis factor ligand superfamily member 13B ELISA Kit
 Tumor necrosis factor ligand superfamily member 13B Recombinant
 Tumor necrosis factor ligand superfamily member 13B Antibody
Also known as Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257).
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important ro
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le in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
 TNFSF13B ELISA Kit
 TNFSF13B Recombinant
 TNFSF13B Antibody
 BAFF ELISA Kit
 BAFF Recombinant
 BAFF Antibody
 BLYS ELISA Kit
 BLYS Recombinant
 BLYS Antibody
 TALL1 ELISA Kit
 TALL1 Recombinant
 TALL1 Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 14

 Tumor necrosis factor ligand superfamily member 14 ELISA Kit
 Tumor necrosis factor ligand superfamily member 14 Recombinant
 Tumor necrosis factor ligand superfamily member 14 Antibody
Also known as Tumor necrosis factor ligand superfamily member 14 (CD antigen CD258).
TNFSF14: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. Belongs to the tumor necrosis factor family. 2 isofor
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ms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Inhibitor; Membrane protein, integral

Cellular Component: plasma membrane

Molecular Function: caspase inhibitor activity; receptor binding

Biological Process: positive regulation of myoblast differentiation; release of cytoplasmic sequestered NF-kappaB; T cell costimulation
 Tnfsf14 ELISA Kit
 Tnfsf14 Recombinant
 Tnfsf14 Antibody
 Light ELISA Kit
 Light Recombinant
 Light Antibody
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Tumor necrosis factor ligand superfamily member 15

 Tumor necrosis factor ligand superfamily member 15 ELISA Kit
 Tumor necrosis factor ligand superfamily member 15 Recombinant
 Tumor necrosis factor ligand superfamily member 15 Antibody
Also known as Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor).
TNFSF15: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q32

Cellular Component
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: integral to plasma membrane; plasma membrane

Molecular Function: receptor binding

Biological Process: activation of NF-kappaB-inducing kinase; caspase activation; cytokine metabolic process; tumor necrosis factor-mediated signaling pathway
 TNFSF15 ELISA Kit
 TNFSF15 Recombinant
 TNFSF15 Antibody
 TL1 ELISA Kit
 TL1 Recombinant
 TL1 Antibody
 VEGI ELISA Kit
 VEGI Recombinant
 VEGI Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 18

 Tumor necrosis factor ligand superfamily member 18 ELISA Kit
 Tumor necrosis factor ligand superfamily member 18 Recombinant
 Tumor necrosis factor ligand superfamily member 18 Antibody
Also known as Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL).
TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromoso
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mal Location of Human Ortholog: 1q23

Cellular Component: cell surface; plasma membrane

Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of NF-kappaB transcription factor; cell-cell signaling; negative regulation of apoptosis; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of T cell proliferation; signal transduction; T cell proliferation during immune response; tumor necrosis factor-mediated signaling pathway
 TNFSF18 ELISA Kit
 TNFSF18 Recombinant
 TNFSF18 Antibody
 AITRL ELISA Kit
 AITRL Recombinant
 AITRL Antibody
 GITRL ELISA Kit
 GITRL Recombinant
 GITRL Antibody
 TL6 ELISA Kit
 TL6 Recombinant
 TL6 Antibody
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Tumor necrosis factor ligand superfamily member 4

 Tumor necrosis factor ligand superfamily member 4 ELISA Kit
 Tumor necrosis factor ligand superfamily member 4 Recombinant
 Tumor necrosis factor ligand superfamily member 4 Antibody
Also known as Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252).
TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammator
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y and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.

Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cell surface; extracellular space; plasma membrane

Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: acute inflammatory response; defense response to nematode; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of regulatory T cell differentiation; negative regulation of T-helper 1 cell differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell activation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of cell proliferation; positive regulation of immunoglobulin mediated immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of memory T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of T-helper 2 type immune response; regulation of adaptive immune response; regulation of inflammatory response; response to virus; signal transduction; tumor necrosis factor-mediated signaling pathway

Disease: Myocardial Infarction, Susceptibility To
 TNFSF4 ELISA Kit
 TNFSF4 Recombinant
 TNFSF4 Antibody
 TXGP1 ELISA Kit
 TXGP1 Recombinant
 TXGP1 Antibody
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Tumor necrosis factor ligand superfamily member 6

 Tumor necrosis factor ligand superfamily member 6 ELISA Kit
 Tumor necrosis factor ligand superfamily member 6 Recombinant
 Tumor necrosis factor ligand superfamily member 6 Antibody
Also known as Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178).
FasL: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (P
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robable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular region; extracellular space; integral to plasma membrane; nucleus; plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: apoptosis; caspase activation; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction

Disease: Autoimmune Lymphoproliferative Syndrome; Lung Cancer
 FASLG ELISA Kit
 FASLG Recombinant
 FASLG Antibody
 APT1LG1 ELISA Kit
 APT1LG1 Recombinant
 APT1LG1 Antibody
 CD95L ELISA Kit
 CD95L Recombinant
 CD95L Antibody
 FASL ELISA Kit
 FASL Recombinant
 FASL Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 8

 Tumor necrosis factor ligand superfamily member 8 ELISA Kit
 Tumor necrosis factor ligand superfamily member 8 Recombinant
 Tumor necrosis factor ligand superfamily member 8 Antibody
Also known as Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153).
TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Biological Process: CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; positive regulation of transcription from RNA polymerase II promoter
 Tnfsf8 ELISA Kit
 Tnfsf8 Recombinant
 Tnfsf8 Antibody
 Cd30l ELISA Kit
 Cd30l Recombinant
 Cd30l Antibody
 Cd30lg ELISA Kit
 Cd30lg Recombinant
 Cd30lg Antibody
Table BarTOPTable Bar
 

Tumor necrosis factor ligand superfamily member 9

 Tumor necrosis factor ligand superfamily member 9 ELISA Kit
 Tumor necrosis factor ligand superfamily member 9 Recombinant
 Tumor necrosis factor ligand superfamily member 9 Antibody
Also known as Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL).
TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral

Cellular Component: plasma membrane

Molecular Function: receptor binding; tumor necrosis factor receptor superfamil
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y binding

Biological Process: cell-cell signaling; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; regulation of cell proliferation
 Tnfsf9 ELISA Kit
 Tnfsf9 Recombinant
 Tnfsf9 Antibody
 Cd137l ELISA Kit
 Cd137l Recombinant
 Cd137l Antibody
 Cd157l ELISA Kit
 Cd157l Recombinant
 Cd157l Antibody
 Ly63l ELISA Kit
 Ly63l Recombinant
 Ly63l Antibody
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