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Tumor protein

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Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Below are the list of possible Tumor protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tumor protein 63

 Tumor protein 63 ELISA Kit
 Tumor protein 63 Recombinant
 Tumor protein 63 Antibody
Also known as Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51).
p63: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to
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genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: cytoplasm; cytosol; dendrite; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: damaged DNA binding; double-stranded DNA binding; identical protein binding; p53 binding; protein binding; sequence-specific DNA binding; transcription factor activity; WW domain binding

Biological Process: apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1 DNA damage checkpoint; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein homotetramerization; regulation of apoptosis; regulation of epidermal cell division; regulation of neuron apoptosis; response to gamma radiation; response to X-ray

Disease: Adult Syndrome; Ankyloblepharon-ectodermal Defects-cleft Lip/palate; Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/palate Syndrome 3; Limb-mammary Syndrome; Rapp-hodgkin Syndrome; Split-hand/foot Malformation 4
 TP63 ELISA Kit
 TP63 Recombinant
 TP63 Antibody
 KET ELISA Kit
 KET Recombinant
 KET Antibody
 P63 ELISA Kit
 P63 Recombinant
 P63 Antibody
 P73H ELISA Kit
 P73H Recombinant
 P73H Antibody
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Tumor protein D52

 Tumor protein D52 ELISA Kit
 Tumor protein D52 Recombinant
 Tumor protein D52 Antibody
Also known as Tumor protein D52 (28 kDa calcium-dependent phosphoprotein) (pp28).
 TPD52 ELISA Kit
 TPD52 Recombinant
 TPD52 Antibody
 CSPP28 ELISA Kit
 CSPP28 Recombinant
 CSPP28 Antibody
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Tumor protein D53

 Tumor protein D53 ELISA Kit
 Tumor protein D53 Recombinant
 Tumor protein D53 Antibody
Also known as Tumor protein D53 (hD53) (Tumor protein D52-like 1).
TPD52L1: a member of the tumor protein D52 (TPD52) family. Contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. Interacts with the apoptosis signal-regulating kinase 1 (ASK1) and positively regulates ASK1-in
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duced apoptosis. Multiple alternatively spliced transcript variants have been observed.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: cytoplasm; perinuclear region of cytoplasm

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: G2/M transition of mitotic cell cycle; positive regulation of JNK cascade; positive regulation of MAP kinase activity
 TPD52L1 ELISA Kit
 TPD52L1 Recombinant
 TPD52L1 Antibody
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Tumor protein D53 homolog

 Tumor protein D53 homolog ELISA Kit
 Tumor protein D53 homolog Recombinant
 Tumor protein D53 homolog Antibody
Also known as Tumor protein D53 homolog (Tumor protein D52-like 1).
 TPD52L1 ELISA Kit
 TPD52L1 Recombinant
 TPD52L1 Antibody
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Tumor protein D54

 Tumor protein D54 ELISA Kit
 Tumor protein D54 Recombinant
 Tumor protein D54 Antibody
Also known as Tumor protein D54 (hD54) (Tumor protein D52-like 2).
This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternat
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ively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]
 TPD52L2 ELISA Kit
 TPD52L2 Recombinant
 TPD52L2 Antibody
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Tumor protein D55

 Tumor protein D55 ELISA Kit
 Tumor protein D55 Recombinant
 Tumor protein D55 Antibody
Also known as Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3).
TPD52L3: a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alt
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ernative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p24.1

Molecular Function: protein binding
 TPD52L3 ELISA Kit
 TPD52L3 Recombinant
 TPD52L3 Antibody
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Tumor protein p73

 Tumor protein p73 ELISA Kit
 Tumor protein p73 Recombinant
 Tumor protein p73 Antibody
Also known as Tumor protein p73 (p53-like transcription factor) (p53-related protein).
p73: a protein of the p53 family of proteins. p73, like p53, may have tumor suppressor activity, but its multiple isoforms possess different and sometimes opposing functions. Participates in the apoptotic response to DNA damage. Phosphorylated in a cell cycle-dependent manner and negatively regulated by CDKs. When overproduced, activates transcription from p53-responsive promoters and induces apoptosis. Nine transactivation competent (TA) or dominant negative (DN) isoforms, derived from alternative-splici
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ng and alternative promoters, have been described. NH2-terminally truncated p73 isoforms (DNp73) may be oncogenic. DNp73 is elevated in a number of cancers and is associated with adverse clinical outcomes and resistance to chemotherapy. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9; forms complex with p53 and CABLES1. Isoform Beta interacts with WWOX; interacts with HECW2.

Protein type: DNA-binding; Transcription factor; Tumor suppressor

Cellular Component: cell junction; chromatin; cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; damaged DNA binding; DNA binding; double-stranded DNA binding; identical protein binding; p53 binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: activation of MAPK activity; cell cycle arrest; cerebrospinal fluid secretion; digestive tract morphogenesis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; forebrain development; G1 DNA damage checkpoint; hippocampus development; inflammatory response; negative regulation of cardiac muscle cell proliferation; negative regulation of JNK activity; negative regulation of neuron apoptosis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron development; positive regulation of apoptosis; positive regulation of cell size; positive regulation of oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic development; regulation of gene expression; regulation of mitotic cell cycle; regulation of neuron apoptosis; release of cytochrome c from mitochondria; response to DNA damage stimulus; response to gamma radiation; response to X-ray
 Tp73 ELISA Kit
 Tp73 Recombinant
 Tp73 Antibody
 P73 ELISA Kit
 P73 Recombinant
 P73 Antibody
 Trp73 ELISA Kit
 Trp73 Recombinant
 Trp73 Antibody
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Proteins Root Name Listing
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