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Tumor protein p53-inducible nuclear protein

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Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Below are the list of possible Tumor protein p53-inducible nuclear protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tumor protein p53-inducible nuclear protein 1

 Tumor protein p53-inducible nuclear protein 1 ELISA Kit
 Tumor protein p53-inducible nuclear protein 1 Recombinant
 Tumor protein p53-inducible nuclear protein 1 Antibody
Also known as Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1).
TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p5
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3/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: autophagic vacuole; cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: antioxidant activity; protein binding

Biological Process: autophagic cell death; autophagic vacuole formation; cell cycle arrest; negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to stress
 TP53INP1 ELISA Kit
 TP53INP1 Recombinant
 TP53INP1 Antibody
 P53DINP1 ELISA Kit
 P53DINP1 Recombinant
 P53DINP1 Antibody
 SIP ELISA Kit
 SIP Recombinant
 SIP Antibody
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Tumor protein p53-inducible nuclear protein 2

 Tumor protein p53-inducible nuclear protein 2 ELISA Kit
 Tumor protein p53-inducible nuclear protein 2 Recombinant
 Tumor protein p53-inducible nuclear protein 2 Antibody
Also known as Tumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene).
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
 Tp53inp2 ELISA Kit
 Tp53inp2 Recombinant
 Tp53inp2 Antibody
 Dor ELISA Kit
 Dor Recombinant
 Dor Antibody
 Trp53inp2 ELISA Kit
 Trp53inp2 Recombinant
 Trp53inp2 Antibody
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