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Tumor suppressor p53-binding protein

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Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation (By similarity).

Below are the list of possible Tumor suppressor p53-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tumor suppressor p53-binding protein 1

 Tumor suppressor p53-binding protein 1 ELISA Kit
 Tumor suppressor p53-binding protein 1 Recombinant
 Tumor suppressor p53-binding protein 1 Antibody
Also known as Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1).
53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg resid
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ues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.

Protein type: DNA repair, damage; Transcription, coactivator/corepressor

Cellular Component: chromosome, telomeric region; cytoplasm; kinetochore; nuclear chromosome, telomeric region; nucleus; replication fork

Molecular Function: damaged DNA binding; histone binding; methylated histone residue binding; p53 binding; protein binding; sequence-specific DNA binding; telomeric DNA binding; transcription factor binding

Biological Process: DNA damage checkpoint; DNA repair; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to DNA damage stimulus
 Tp53bp1 ELISA Kit
 Tp53bp1 Recombinant
 Tp53bp1 Antibody
 Trp53bp1 ELISA Kit
 Trp53bp1 Recombinant
 Trp53bp1 Antibody
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