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Tumor susceptibility gene 101 protein

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Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan .

Below are the list of possible Tumor susceptibility gene 101 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tumor susceptibility gene 101 protein

 Tumor susceptibility gene 101 protein ELISA Kit
 Tumor susceptibility gene 101 protein Recombinant
 Tumor susceptibility gene 101 protein Antibody
Also known as Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101).
TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for compl
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etion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; early endosome; endosome; endosome membrane; late endosome; multivesicular body; nucleolus; plasma membrane

Molecular Function: calcium-dependent protein binding; DNA binding; protein binding; protein homodimerization activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding

Biological Process: autophagy; endosome transport; negative regulation of epidermal growth factor receptor signaling pathway; non-lytic virus budding; positive regulation of viral reproduction; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral infectious cycle

Disease: Breast Cancer
 TSG101 ELISA Kit
 TSG101 Recombinant
 TSG101 Antibody
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