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Type II iodothyronine deiodinase

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Catalyzes the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Below are the list of possible Type II iodothyronine deiodinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Type II iodothyronine deiodinase

 Type II iodothyronine deiodinase ELISA Kit
 Type II iodothyronine deiodinase Recombinant
 Type II iodothyronine deiodinase Antibody
Also known as Type II iodothyronine deiodinase (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase).
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is expressed in a few tissues in rat, including brain, pituitary and brown adipose tissue. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tis
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sues. Studies in rat suggest that this gene may play an important role in the regulation of lipid metabolism and thermogenesis, and in osteoarthritis pathogenesis by enhancing the chondrocyte hypertrophy and inflammatory response. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, May 2016]
 Dio2 ELISA Kit
 Dio2 Recombinant
 Dio2 Antibody
 Itdi2 ELISA Kit
 Itdi2 Recombinant
 Itdi2 Antibody
 Txdi2 ELISA Kit
 Txdi2 Recombinant
 Txdi2 Antibody
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