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Tyrosine-protein kinase

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CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. .

Below are the list of possible Tyrosine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tyrosine protein-kinase src-1

 Tyrosine protein-kinase src-1 ELISA Kit
 Tyrosine protein-kinase src-1 Recombinant
 Tyrosine protein-kinase src-1 Antibody
Also known as Tyrosine protein-kinase src-1 (SRC oncogene related protein 1).
Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, Pub
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Med:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
 src-1 ELISA Kit
 src-1 Recombinant
 src-1 Antibody
 Y92H12A.1 ELISA Kit
 Y92H12A.1 Recombinant
 Y92H12A.1 Antibody
Table BarTOPTable Bar
 

Tyrosine protein-kinase src-2

 Tyrosine protein-kinase src-2 ELISA Kit
 Tyrosine protein-kinase src-2 Recombinant
 Tyrosine protein-kinase src-2 Antibody
Also known as Tyrosine protein-kinase src-2 (SRC oncogene related protein 2).
Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.
 src-2 ELISA Kit
 src-2 Recombinant
 src-2 Antibody
 kin-22 ELISA Kit
 kin-22 Recombinant
 kin-22 Antibody
 F49B2.5 ELISA Kit
 F49B2.5 Recombinant
 F49B2.5 Antibody
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Tyrosine-protein kinase ABL

 Tyrosine-protein kinase ABL ELISA Kit
 Tyrosine-protein kinase ABL Recombinant
 Tyrosine-protein kinase ABL Antibody
 ABL ELISA Kit
 ABL Recombinant
 ABL Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase abl-1

 Tyrosine-protein kinase abl-1 ELISA Kit
 Tyrosine-protein kinase abl-1 Recombinant
 Tyrosine-protein kinase abl-1 Antibody
Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses.
 abl-1 ELISA Kit
 abl-1 Recombinant
 abl-1 Antibody
 M79.1 ELISA Kit
 M79.1 Recombinant
 M79.1 Antibody
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Tyrosine-protein kinase ABL1

 Tyrosine-protein kinase ABL1 ELISA Kit
 Tyrosine-protein kinase ABL1 Recombinant
 Tyrosine-protein kinase ABL1 Antibody
Also known as Tyrosine-protein kinase ABL1 (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150).
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosp
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horylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
 ABL1 ELISA Kit
 ABL1 Recombinant
 ABL1 Antibody
 ABL ELISA Kit
 ABL Recombinant
 ABL Antibody
 JTK7 ELISA Kit
 JTK7 Recombinant
 JTK7 Antibody
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Tyrosine-protein kinase BAZ1B

 Tyrosine-protein kinase BAZ1B ELISA Kit
 Tyrosine-protein kinase BAZ1B Recombinant
 Tyrosine-protein kinase BAZ1B Antibody
Also known as Tyrosine-protein kinase BAZ1B (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor homolog).
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in
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DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes.
 baz1b ELISA Kit
 baz1b Recombinant
 baz1b Antibody
 wstf ELISA Kit
 wstf Recombinant
 wstf Antibody
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Tyrosine-protein kinase Blk

 Tyrosine-protein kinase Blk ELISA Kit
 Tyrosine-protein kinase Blk Recombinant
 Tyrosine-protein kinase Blk Antibody
Also known as Tyrosine-protein kinase Blk (B lymphocyte kinase) (p55-Blk).
BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 8p23-p22

Cellular Component: extrinsic t
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o internal side of plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: B cell receptor signaling pathway; cell differentiation; cytoskeleton organization and biogenesis; innate immune response; negative regulation of apoptosis; positive regulation of insulin secretion; regulation of cell proliferation; regulation of phagocytosis; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Maturity-onset Diabetes Of The Young, Type 11
 BLK ELISA Kit
 BLK Recombinant
 BLK Antibody
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Tyrosine-protein kinase BTK

 Tyrosine-protein kinase BTK ELISA Kit
 Tyrosine-protein kinase BTK Recombinant
 Tyrosine-protein kinase BTK Antibody
Also known as Tyrosine-protein kinase BTK (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase).
Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.

Protein type: EC 2.7.10.2; Kinase, protein; Pr
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otein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: Xq21.33-q22

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; nucleus; plasma membrane

Molecular Function: ATP binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; innate immune response; mesoderm development; MyD88-dependent toll-like receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of B cell differentiation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell cytokine production; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Agammaglobulinemia, X-linked; Isolated Growth Hormone Deficiency, Type Iii
 BTK ELISA Kit
 BTK Recombinant
 BTK Antibody
 AGMX1 ELISA Kit
 AGMX1 Recombinant
 AGMX1 Antibody
 ATK ELISA Kit
 ATK Recombinant
 ATK Antibody
 BPK ELISA Kit
 BPK Recombinant
 BPK Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Btk29A

 Tyrosine-protein kinase Btk29A ELISA Kit
 Tyrosine-protein kinase Btk29A Recombinant
 Tyrosine-protein kinase Btk29A Antibody
Also known as Tyrosine-protein kinase Btk29A (Dsrc28C) (Dsrc29a).
Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.
 Btk29A ELISA Kit
 Btk29A Recombinant
 Btk29A Antibody
 Src2 ELISA Kit
 Src2 Recombinant
 Src2 Antibody
 Src29A ELISA Kit
 Src29A Recombinant
 Src29A Antibody
 Tec29 ELISA Kit
 Tec29 Recombinant
 Tec29 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase CpsD

 Tyrosine-protein kinase CpsD ELISA Kit
 Tyrosine-protein kinase CpsD Recombinant
 Tyrosine-protein kinase CpsD Antibody
Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide ().
 cpsD ELISA Kit
 cpsD Recombinant
 cpsD Antibody
 gbs1245 ELISA Kit
 gbs1245 Recombinant
 gbs1245 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase CSK

 Tyrosine-protein kinase CSK ELISA Kit
 Tyrosine-protein kinase CSK Recombinant
 Tyrosine-protein kinase CSK Antibody
Also known as Tyrosine-protein kinase CSK (C-Src kinase).
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage i
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n intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK ().
 CSK ELISA Kit
 CSK Recombinant
 CSK Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase csk-1

 Tyrosine-protein kinase csk-1 ELISA Kit
 Tyrosine-protein kinase csk-1 Recombinant
 Tyrosine-protein kinase csk-1 Antibody
Also known as Tyrosine-protein kinase csk-1 (C-terminal src kinase).
Non-receptor tyrosine-protein kinase which plays a role in pharynx function by regulating pumping and the orientation of pharyngeal muscle fibers, independently of src-1 and src-2 (PubMed:19210548). May phosphorylate and thereby negatively regulate src-1 and src-2 activities (PubMed:12527374).
 csk-1 ELISA Kit
 csk-1 Recombinant
 csk-1 Antibody
 Y48G1C.2 ELISA Kit
 Y48G1C.2 Recombinant
 Y48G1C.2 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Dnt

 Tyrosine-protein kinase Dnt ELISA Kit
 Tyrosine-protein kinase Dnt Recombinant
 Tyrosine-protein kinase Dnt Antibody
Also known as Tyrosine-protein kinase Dnt (Protein doughnut).
May play an essential role in neuronal pathway recognition and ventral muscle attachment site selection.
 dnt ELISA Kit
 dnt Recombinant
 dnt Antibody
 CG17559 ELISA Kit
 CG17559 Recombinant
 CG17559 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Drl

 Tyrosine-protein kinase Drl ELISA Kit
 Tyrosine-protein kinase Drl Recombinant
 Tyrosine-protein kinase Drl Antibody
Also known as Tyrosine-protein kinase Drl (Protein derailed).
Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non-vital for development. May be part of a signal transduction cascade involved in learning and possibly memory.
 drl ELISA Kit
 drl Recombinant
 drl Antibody
 lio ELISA Kit
 lio Recombinant
 lio Antibody
 CG17348 ELISA Kit
 CG17348 Recombinant
 CG17348 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase etk

 Tyrosine-protein kinase etk ELISA Kit
 Tyrosine-protein kinase etk Recombinant
 Tyrosine-protein kinase etk Antibody
 etk ELISA Kit
 etk Recombinant
 etk Antibody
 yccC ELISA Kit
 yccC Recombinant
 yccC Antibody
 b0981 ELISA Kit
 b0981 Recombinant
 b0981 Antibody
 JW0964 ELISA Kit
 JW0964 Recombinant
 JW0964 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Fer

 Tyrosine-protein kinase Fer ELISA Kit
 Tyrosine-protein kinase Fer Recombinant
 Tyrosine-protein kinase Fer Antibody
Tyrosine-protein kinase which is required during embryogenesis for formation of the actin cable in leading edge cells of the dorsal epidermis and for the timely progression of dorsal closure. May play a role in regulation of adherens junctions and cell adhesion through phosphorylation of the beta-catenin arm.
 FER ELISA Kit
 FER Recombinant
 FER Antibody
 fps ELISA Kit
 fps Recombinant
 fps Antibody
 Fps85D ELISA Kit
 Fps85D Recombinant
 Fps85D Antibody
 HD-179 ELISA Kit
 HD-179 Recombinant
 HD-179 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Fes/Fps

 Tyrosine-protein kinase Fes/Fps ELISA Kit
 Tyrosine-protein kinase Fes/Fps Recombinant
 Tyrosine-protein kinase Fes/Fps Antibody
Also known as Tyrosine-protein kinase Fes/Fps (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes).
Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colo
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rectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.

Protein type: EC 2.7.10.2; Fer family; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tumor suppressor

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; microtubule cytoskeleton

Molecular Function: non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; protein binding; protein-tyrosine kinase activity

Biological Process: cell proliferation; chemotaxis; epidermal growth factor receptor signaling pathway; innate immune response; multicellular organismal development; peptidyl-tyrosine phosphorylation; positive regulation of microtubule polymerization; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of cell proliferation; regulation of cell shape; regulation of mast cell degranulation
 FES ELISA Kit
 FES Recombinant
 FES Antibody
 FPS ELISA Kit
 FPS Recombinant
 FPS Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Fgr

 Tyrosine-protein kinase Fgr ELISA Kit
 Tyrosine-protein kinase Fgr Recombinant
 Tyrosine-protein kinase Fgr Antibody
Also known as Tyrosine-protein kinase Fgr (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr).
FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplif
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ied in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers.

Protein type: EC 2.7.10.2; Kinase, protein; Mitochondrial; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 1p36.2-p36.1

Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase binding; protein-tyrosine kinase activity

Biological Process: cell differentiation; cell migration; defense response to Gram-positive bacterium; immune response-regulating cell surface receptor signaling pathway; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell migration; positive regulation of cytokine secretion; positive regulation of mast cell degranulation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of innate immune response; regulation of phagocytosis; regulation of protein kinase activity; response to virus; transmembrane receptor protein tyrosine kinase signaling pathway
 FGR ELISA Kit
 FGR Recombinant
 FGR Antibody
 SRC2 ELISA Kit
 SRC2 Recombinant
 SRC2 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase FRK

 Tyrosine-protein kinase FRK ELISA Kit
 Tyrosine-protein kinase FRK Recombinant
 Tyrosine-protein kinase FRK Antibody
Also known as Tyrosine-protein kinase FRK (Beta-cell Src-homology tyrosine kinase) (BSK) (FYN-related kinase) (Intestine tyrosine kinase).
FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group; Tumor suppressor

Cellular Component: cytoplasm; extrinsic to internal side of pl
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asma membrane; intracellular membrane-bound organelle; nucleus; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; innate immune response; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
 Frk ELISA Kit
 Frk Recombinant
 Frk Antibody
 Bsk ELISA Kit
 Bsk Recombinant
 Bsk Antibody
 Iyk ELISA Kit
 Iyk Recombinant
 Iyk Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Fyn

 Tyrosine-protein kinase Fyn ELISA Kit
 Tyrosine-protein kinase Fyn Recombinant
 Tyrosine-protein kinase Fyn Antibody
Also known as Tyrosine-protein kinase Fyn (Proto-oncogene c-Fyn) (p59-Fyn).
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the cat
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alytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1 (). Interacts with UNC119 ().
 FYN ELISA Kit
 FYN Recombinant
 FYN Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase fyna

 Tyrosine-protein kinase fyna ELISA Kit
 Tyrosine-protein kinase fyna Recombinant
 Tyrosine-protein kinase fyna Antibody
Also known as Tyrosine-protein kinase fyna (Proto-oncogene c-Fyna).
Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (). Required for
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convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling.
 fyna ELISA Kit
 fyna Recombinant
 fyna Antibody
 fyn ELISA Kit
 fyn Recombinant
 fyn Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase fynb

 Tyrosine-protein kinase fynb ELISA Kit
 Tyrosine-protein kinase fynb Recombinant
 Tyrosine-protein kinase fynb Antibody
Also known as Tyrosine-protein kinase fynb (Proto-oncogene c-Fynb).
Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling ().
 fynb ELISA Kit
 fynb Recombinant
 fynb Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase HCK

 Tyrosine-protein kinase HCK ELISA Kit
 Tyrosine-protein kinase HCK Recombinant
 Tyrosine-protein kinase HCK Antibody
Also known as Tyrosine-protein kinase HCK (B-cell/myeloid kinase) (BMK) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p56-HCK/p59-HCK).
Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil mi
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gration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Cellular Component: actin filament; caveola; extrinsic to internal side of plasma membrane; focal adhesion; lysosome

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cytoskeleton organization and biogenesis; defense response to Gram-positive bacterium; innate immune response; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; phagocytosis; positive regulation of cell proliferation; protein amino acid autophosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of phagocytosis; regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway
 Hck ELISA Kit
 Hck Recombinant
 Hck Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase HTK16

 Tyrosine-protein kinase HTK16 ELISA Kit
 Tyrosine-protein kinase HTK16 Recombinant
 Tyrosine-protein kinase HTK16 Antibody
May be involved in signal transduction.
 HTK16 ELISA Kit
 HTK16 Recombinant
 HTK16 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase isoform SRK1

 Tyrosine-protein kinase isoform SRK1 ELISA Kit
 Tyrosine-protein kinase isoform SRK1 Recombinant
 Tyrosine-protein kinase isoform SRK1 Antibody
 SRK1 ELISA Kit
 SRK1 Recombinant
 SRK1 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase isoform SRK4

 Tyrosine-protein kinase isoform SRK4 ELISA Kit
 Tyrosine-protein kinase isoform SRK4 Recombinant
 Tyrosine-protein kinase isoform SRK4 Antibody
 SRK1 ELISA Kit
 SRK1 Recombinant
 SRK1 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase ITK/TSK

 Tyrosine-protein kinase ITK/TSK ELISA Kit
 Tyrosine-protein kinase ITK/TSK Recombinant
 Tyrosine-protein kinase ITK/TSK Antibody
Also known as Tyrosine-protein kinase ITK/TSK (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) (T-cell-specific kinase).
ITK: an intracellular tyrosine kinase of the Tec family expressed in T-cells. Plays an essential role in regulation of the adaptive immune response. Contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Is recruited to the cell membrane following activation of the T-cell receptor (TCR). It is phosphorylated by LC
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K, followed by autophosphorylation leading to its full activation. Phosphorylates PLCG1. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Cellular Component: extrinsic to internal side of plasma membrane; intercellular junction

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding

Biological Process: adaptive immune response; cytokine production; innate immune response; interferon-gamma production; interleukin-4 production; NK T cell differentiation; phospholipase C activation; regulation of cell proliferation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
 Itk ELISA Kit
 Itk Recombinant
 Itk Antibody
 Emt ELISA Kit
 Emt Recombinant
 Emt Antibody
 Tlk ELISA Kit
 Tlk Recombinant
 Tlk Antibody
 Tsk ELISA Kit
 Tsk Recombinant
 Tsk Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase JAK1

 Tyrosine-protein kinase JAK1 ELISA Kit
 Tyrosine-protein kinase JAK1 Recombinant
 Tyrosine-protein kinase JAK1 Antibody
Also known as Tyrosine-protein kinase JAK1 (Janus kinase 1) (JAK-1).
Tyrosine kinase of the non-receptor type.
 jak1 ELISA Kit
 jak1 Recombinant
 jak1 Antibody
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Tyrosine-protein kinase JAK2

 Tyrosine-protein kinase JAK2 ELISA Kit
 Tyrosine-protein kinase JAK2 Recombinant
 Tyrosine-protein kinase JAK2 Antibody
Also known as Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2).
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling
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for many members of the cytokine receptor superfamily. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin ().
 JAK2 ELISA Kit
 JAK2 Recombinant
 JAK2 Antibody
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Tyrosine-protein kinase JAK3

 Tyrosine-protein kinase JAK3 ELISA Kit
 Tyrosine-protein kinase JAK3 Recombinant
 Tyrosine-protein kinase JAK3 Antibody
Also known as Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3).
JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM
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2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.

Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; receptor binding

Biological Process: B cell differentiation; cell migration; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; enzyme linked receptor protein signaling pathway; innate immune response; lymph node development; negative regulation of dendritic cell cytokine production; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; negative regulation of T cell activation; negative regulation of T-helper 1 cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway
 Jak3 ELISA Kit
 Jak3 Recombinant
 Jak3 Antibody
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Tyrosine-protein kinase Lck

 Tyrosine-protein kinase Lck ELISA Kit
 Tyrosine-protein kinase Lck Recombinant
 Tyrosine-protein kinase Lck Antibody
Also known as Tyrosine-protein kinase Lck (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK).
Lck: a tyrosine kinase of the Src family that is crucial to antigen-receptor signaling in lymphocytes. plays an essential role for the selection and maturation of developing T
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-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Binds to the cytoplasmic domain of cell surface receptors, such as CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB and to other protein kinases including CDC2, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of Sam68 through its SH2 domain. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Overexpression in mice leads to thymic tumors. Aberrant expression is seen in T cell leukemias and colon cancer. The leukemic translocation t(1;7)(p34;q34) has breakpoints at the T cell receptor gene and close to the Lck promoters, can cause increased Lck expression, and in one case, point mutations. A mutated Lck has also been seen in a cell line. One patient with aberrant Lck splicing suffered from SCID-like T cell deficiency. Inhibitor: BMS-279700. Three alternatively spliced isoforms of the human proteinhave been described.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; immunological synapse; lipid raft; pericentriolar material; plasma membrane

Molecular Function: ATPase binding; CD4 receptor binding; CD8 receptor binding; glycoprotein binding; identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein serine/threonine phosphatase activity; protein-tyrosine kinase activity; SH2 domain binding

Biological Process: B cell receptor signaling pathway; caspase activation; cellular zinc ion homeostasis; innate immune response; leukocyte migration; phosphoinositide-mediated signaling; platelet activation; positive regulation of T cell activation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of defense response to virus by virus; regulation of phosphoinositide 3-kinase cascade; release of sequestered calcium ion into cytosol; response to drug; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Immunodeficiency 22
 LCK ELISA Kit
 LCK Recombinant
 LCK Antibody
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Tyrosine-protein kinase Lyn

 Tyrosine-protein kinase Lyn ELISA Kit
 Tyrosine-protein kinase Lyn Recombinant
 Tyrosine-protein kinase Lyn Antibody
Also known as Tyrosine-protein kinase Lyn (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn).
LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src fam
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ily; TK group

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi apparatus; lipid raft; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; receptor signaling protein tyrosine kinase activity

Biological Process: B cell homeostasis; blood coagulation; central nervous system development; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; immune response-regulating cell surface receptor signaling pathway; inflammatory response; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of immune response; negative regulation of MAP kinase activity; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of erythrocyte differentiation; regulation of mast cell activation; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; response to DNA damage stimulus; response to hormone stimulus; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway
 LYN ELISA Kit
 LYN Recombinant
 LYN Antibody
 JTK8 ELISA Kit
 JTK8 Recombinant
 JTK8 Antibody
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Tyrosine-protein kinase MasK

 Tyrosine-protein kinase MasK ELISA Kit
 Tyrosine-protein kinase MasK Recombinant
 Tyrosine-protein kinase MasK Antibody
Essential for growth. Interacts with MglA to control social gliding motility.
 masK ELISA Kit
 masK Recombinant
 masK Antibody
 MXAN_1929 ELISA Kit
 MXAN_1929 Recombinant
 MXAN_1929 Antibody
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Tyrosine-protein kinase Mer

 Tyrosine-protein kinase Mer ELISA Kit
 Tyrosine-protein kinase Mer Recombinant
 Tyrosine-protein kinase Mer Antibody
Also known as Tyrosine-protein kinase Mer (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK).
Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the
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retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Protein type: Axl family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: cytoplasm; extracellular space; photoreceptor outer segment

Biological Process: apoptotic cell clearance; natural killer cell differentiation; negative regulation of cytokine production; negative regulation of lymphocyte activation; phagocytosis; platelet activation; positive regulation of phagocytosis; protein amino acid phosphorylation; protein kinase B signaling cascade; retina development in camera-type eye; secretion by cell; spermatogenesis; vagina development
 Mertk ELISA Kit
 Mertk Recombinant
 Mertk Antibody
 Mer ELISA Kit
 Mer Recombinant
 Mer Antibody
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Tyrosine-protein kinase PR2

 Tyrosine-protein kinase PR2 ELISA Kit
 Tyrosine-protein kinase PR2 Recombinant
 Tyrosine-protein kinase PR2 Antibody
 PR2 ELISA Kit
 PR2 Recombinant
 PR2 Antibody
 CG3969 ELISA Kit
 CG3969 Recombinant
 CG3969 Antibody
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Tyrosine-protein kinase ptk

 Tyrosine-protein kinase ptk ELISA Kit
 Tyrosine-protein kinase ptk Recombinant
 Tyrosine-protein kinase ptk Antibody
May be involved in the production and the transport of exopolysaccharides.
 ptk ELISA Kit
 ptk Recombinant
 ptk Antibody
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Tyrosine-protein kinase RYK

 Tyrosine-protein kinase RYK ELISA Kit
 Tyrosine-protein kinase RYK Recombinant
 Tyrosine-protein kinase RYK Antibody
RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor
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); Ryk family; TK group

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: cytoplasm; integral to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: frizzled binding; protein binding; protein-tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding

Biological Process: axon guidance; axonogenesis; cell proliferation in midbrain; corpus callosum development; neurite development; neuron differentiation; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway
 RYK ELISA Kit
 RYK Recombinant
 RYK Antibody
 JTK5A ELISA Kit
 JTK5A Recombinant
 JTK5A Antibody
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Tyrosine-protein kinase SgK223

 Tyrosine-protein kinase SgK223 ELISA Kit
 Tyrosine-protein kinase SgK223 Recombinant
 Tyrosine-protein kinase SgK223 Antibody
Also known as Tyrosine-protein kinase SgK223 (Sugen kinase 223).
SGK223: a protein kinase of the NKF3 family.

Protein type: EC 2.7.10.2; Kinase, protein; Motility/polarity/chemotaxis; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Molecular Function: protein kinase activity
 Sgk223 ELISA Kit
 Sgk223 Recombinant
 Sgk223 Antibody
 D8Ertd82e ELISA Kit
 D8Ertd82e Recombinant
 D8Ertd82e Antibody
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Tyrosine-protein kinase shark

 Tyrosine-protein kinase shark ELISA Kit
 Tyrosine-protein kinase shark Recombinant
 Tyrosine-protein kinase shark Antibody
Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system (PubMed:18432193). Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity du
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ring invagination (PubMed:7892198). Crumbs (crb) may be the intracellular signal (PubMed:7892198).
 shark ELISA Kit
 shark Recombinant
 shark Antibody
 Tk7 ELISA Kit
 Tk7 Recombinant
 Tk7 Antibody
 CG18247 ELISA Kit
 CG18247 Recombinant
 CG18247 Antibody
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Tyrosine-protein kinase sid-3

 Tyrosine-protein kinase sid-3 ELISA Kit
 Tyrosine-protein kinase sid-3 Recombinant
 Tyrosine-protein kinase sid-3 Antibody
Also known as Tyrosine-protein kinase sid-3 (Systemic RNA interference defective protein 3) (Systemic RNAi enabling protein).
Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal ti
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ssues.
 sid-3 ELISA Kit
 sid-3 Recombinant
 sid-3 Antibody
 B0302.1 ELISA Kit
 B0302.1 Recombinant
 B0302.1 Antibody
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Tyrosine-protein kinase SPK-1

 Tyrosine-protein kinase SPK-1 ELISA Kit
 Tyrosine-protein kinase SPK-1 Recombinant
 Tyrosine-protein kinase SPK-1 Antibody
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Tyrosine-protein kinase Src-1

 Tyrosine-protein kinase Src-1 ELISA Kit
 Tyrosine-protein kinase Src-1 Recombinant
 Tyrosine-protein kinase Src-1 Antibody
Also known as Tyrosine-protein kinase Src-1 (p60-Src-1).
 src-a ELISA Kit
 src-a Recombinant
 src-a Antibody
 src1 ELISA Kit
 src1 Recombinant
 src1 Antibody
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Tyrosine-protein kinase Src-2

 Tyrosine-protein kinase Src-2 ELISA Kit
 Tyrosine-protein kinase Src-2 Recombinant
 Tyrosine-protein kinase Src-2 Antibody
Also known as Tyrosine-protein kinase Src-2 (p60-Src-2).
 src-b ELISA Kit
 src-b Recombinant
 src-b Antibody
 src2 ELISA Kit
 src2 Recombinant
 src2 Antibody
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Tyrosine-protein kinase Src42A

 Tyrosine-protein kinase Src42A ELISA Kit
 Tyrosine-protein kinase Src42A Recombinant
 Tyrosine-protein kinase Src42A Antibody
Also known as Tyrosine-protein kinase Src42A (Tyrosine-protein kinase Src41) (Dsrc41).
Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morph
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ogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834).
 Src42A ELISA Kit
 Src42A Recombinant
 Src42A Antibody
 Src41 ELISA Kit
 Src41 Recombinant
 Src41 Antibody
 TK5 ELISA Kit
 TK5 Recombinant
 TK5 Antibody
 CG44128 ELISA Kit
 CG44128 Recombinant
 CG44128 Antibody
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Tyrosine-protein kinase Src64B

 Tyrosine-protein kinase Src64B ELISA Kit
 Tyrosine-protein kinase Src64B Recombinant
 Tyrosine-protein kinase Src64B Antibody
Also known as Tyrosine-protein kinase Src64B (Dsrc64).
May play a role in the development of neural tissue and smooth muscle.
 Src64B ELISA Kit
 Src64B Recombinant
 Src64B Antibody
 Src1 ELISA Kit
 Src1 Recombinant
 Src1 Antibody
 CG7524 ELISA Kit
 CG7524 Recombinant
 CG7524 Antibody
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Tyrosine-protein kinase SRK2

 Tyrosine-protein kinase SRK2 ELISA Kit
 Tyrosine-protein kinase SRK2 Recombinant
 Tyrosine-protein kinase SRK2 Antibody
 SRK2 ELISA Kit
 SRK2 Recombinant
 SRK2 Antibody
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Tyrosine-protein kinase SRK3

 Tyrosine-protein kinase SRK3 ELISA Kit
 Tyrosine-protein kinase SRK3 Recombinant
 Tyrosine-protein kinase SRK3 Antibody
 SRK3 ELISA Kit
 SRK3 Recombinant
 SRK3 Antibody
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Tyrosine-protein kinase Srms

 Tyrosine-protein kinase Srms ELISA Kit
 Tyrosine-protein kinase Srms Recombinant
 Tyrosine-protein kinase Srms Antibody
SRMS: a tyrosine kinase of the Src family.

Protein type: EC 2.7.10.2; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: -

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane

Molecular Function: non-membrane spanning pr
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otein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cell migration; innate immune response; negative regulation of signal transduction; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
 SRMS ELISA Kit
 SRMS Recombinant
 SRMS Antibody
 C20orf148 ELISA Kit
 C20orf148 Recombinant
 C20orf148 Antibody
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Tyrosine-protein kinase STK

 Tyrosine-protein kinase STK ELISA Kit
 Tyrosine-protein kinase STK Recombinant
 Tyrosine-protein kinase STK Antibody
Also known as Tyrosine-protein kinase STK (P57-STK).
 STK ELISA Kit
 STK Recombinant
 STK Antibody
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Tyrosine-protein kinase STYK1

 Tyrosine-protein kinase STYK1 ELISA Kit
 Tyrosine-protein kinase STYK1 Recombinant
 Tyrosine-protein kinase STYK1 Antibody
Also known as Tyrosine-protein kinase STYK1 (Novel oncogene with kinase domain) (mNOK) (Serine/threonine/tyrosine kinase 1).
STYK1: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinosit
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ol 3'-kinases (PI3K) pathways. Belongs to the protein kinase superfamily. Tyr protein kinase family.

Protein type: EC 2.7.10.2; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; TK-Unique family

Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cell migration; innate immune response; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
 Styk1 ELISA Kit
 Styk1 Recombinant
 Styk1 Antibody
 Nok ELISA Kit
 Nok Recombinant
 Nok Antibody
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Tyrosine-protein kinase SYK

 Tyrosine-protein kinase SYK ELISA Kit
 Tyrosine-protein kinase SYK Recombinant
 Tyrosine-protein kinase SYK Antibody
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated rece
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ptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors.
 SYK ELISA Kit
 SYK Recombinant
 SYK Antibody
 RCJMB04_19o18 ELISA Kit
 RCJMB04_19o18 Recombinant
 RCJMB04_19o18 Antibody
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Tyrosine-protein kinase Tec

 Tyrosine-protein kinase Tec ELISA Kit
 Tyrosine-protein kinase Tec Recombinant
 Tyrosine-protein kinase Tec Antibody
TEC: a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system.

Protein type:
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EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cytoskeleton; cytosol; extrinsic to internal side of plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding

Biological Process: B cell receptor signaling pathway; cell differentiation; innate immune response; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
 TEC ELISA Kit
 TEC Recombinant
 TEC Antibody
 PSCTK4 ELISA Kit
 PSCTK4 Recombinant
 PSCTK4 Antibody
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Tyrosine-protein kinase TXK

 Tyrosine-protein kinase TXK ELISA Kit
 Tyrosine-protein kinase TXK Recombinant
 Tyrosine-protein kinase TXK Antibody
Also known as Tyrosine-protein kinase TXK (Protein-tyrosine kinase 4) (Resting lymphocyte kinase).
TXK: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from
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many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; nucleus

Molecular Function: protein binding; receptor binding

Biological Process: adaptive immune response; cell differentiation; cytokine production; integrin-mediated signaling pathway; phospholipase C activation; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
 TXK ELISA Kit
 TXK Recombinant
 TXK Antibody
 PTK4 ELISA Kit
 PTK4 Recombinant
 PTK4 Antibody
 RLK ELISA Kit
 RLK Recombinant
 RLK Antibody
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Tyrosine-protein kinase wzc

 Tyrosine-protein kinase wzc ELISA Kit
 Tyrosine-protein kinase wzc Recombinant
 Tyrosine-protein kinase wzc Antibody
Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg.
 wzc ELISA Kit
 wzc Recombinant
 wzc Antibody
 b2060 ELISA Kit
 b2060 Recombinant
 b2060 Antibody
 JW2045 ELISA Kit
 JW2045 Recombinant
 JW2045 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein kinase Yes

 Tyrosine-protein kinase Yes ELISA Kit
 Tyrosine-protein kinase Yes Recombinant
 Tyrosine-protein kinase Yes Antibody
Also known as Tyrosine-protein kinase Yes (p61-Yes).
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis.
 yes1 ELISA Kit
 yes1 Recombinant
 yes1 Antibody
 yes ELISA Kit
 yes Recombinant
 yes Antibody
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Tyrosine-protein kinase YwqD

 Tyrosine-protein kinase YwqD ELISA Kit
 Tyrosine-protein kinase YwqD Recombinant
 Tyrosine-protein kinase YwqD Antibody
May be involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylates in vitro. Phosphorylates and activates in vitro two UDP-glucose dehydrogenases, YwqF and TuaD, as well as the DNA-binding proteins Ssb and SsbB.
 ywqD ELISA Kit
 ywqD Recombinant
 ywqD Antibody
 BSU36250 ELISA Kit
 BSU36250 Recombinant
 BSU36250 Antibody
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Tyrosine-protein kinase ZAP-70

 Tyrosine-protein kinase ZAP-70 ELISA Kit
 Tyrosine-protein kinase ZAP-70 Recombinant
 Tyrosine-protein kinase ZAP-70 Antibody
Also known as Tyrosine-protein kinase ZAP-70 (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase).
ZAP70: a tyrosine kinase of the Syk family. Plays an essential role in regulation of the adaptive immune response. Phosphorylates two essential T cell adapter proteins: the linker for activation of T-cells (LAT) protein and LCP2. Regulates lymphocyte activation, motility, adhesion
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and cytokine expression of mature T-cells. Promotes survival and cell-cycle progression of developing double-negative thymocytes before positive selection. Associates with the T-cell antigen receptor (TCR) zeta-chain and is phosphorylated by Lck following antigen receptor activation. Required for internalization and degradation of the TCR complex through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Three alternatively spliced isoforms of the human protein have been described.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Syk family; TK group

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; lipid raft; plasma membrane; T cell receptor complex

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: adaptive immune response; B cell activation; B cell receptor signaling pathway; immune response; inflammatory response; innate immune response; macrophage activation during immune response; neutrophil activation during immune response; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; positive regulation of T cell differentiation; positive thymic T cell selection; protein amino acid phosphorylation; T cell activation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Autoimmune Disease, Multisystem, Infantile-onset, 2; Selective T-cell Defect
 ZAP70 ELISA Kit
 ZAP70 Recombinant
 ZAP70 Antibody
 SRK ELISA Kit
 SRK Recombinant
 SRK Antibody
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Tyrosine-protein kinase-like otk

 Tyrosine-protein kinase-like otk ELISA Kit
 Tyrosine-protein kinase-like otk Recombinant
 Tyrosine-protein kinase-like otk Antibody
Also known as Tyrosine-protein kinase-like otk (Gp160-Dtrk) (Dtrk) (Off-track) (Tyrosine-protein kinase-like 7 homolog).
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a rece
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ptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.
 otk ELISA Kit
 otk Recombinant
 otk Antibody
 CG8967 ELISA Kit
 CG8967 Recombinant
 CG8967 Antibody
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