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Tyrosine-protein phosphatase non-receptor

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May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).

Below are the list of possible Tyrosine-protein phosphatase non-receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Tyrosine-protein phosphatase non-receptor type 1

 Tyrosine-protein phosphatase non-receptor type 1 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 1 Recombinant
 Tyrosine-protein phosphatase non-receptor type 1 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 1 (CPTP1) (Protein-tyrosine phosphatase 1B) (PTP-1B).
PTP1B: a non-receptor phospho-tyrosine protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation and inactivation of PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May r
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egulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. Negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor. Also reported to dephosphorylate integrin, epidermal growth factor receptor, JAK2 and TYK2, regulating cell growth control and the cellular response to interferon. May regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: early endosome; plasma membrane

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: actin cytoskeleton reorganization; regulation of endocytosis; regulation of signal transduction; unfolded protein response
 PTPN1 ELISA Kit
 PTPN1 Recombinant
 PTPN1 Antibody
 PTP1B ELISA Kit
 PTP1B Recombinant
 PTP1B Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 11

 Tyrosine-protein phosphatase non-receptor type 11 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 11 Recombinant
 Tyrosine-protein phosphatase non-receptor type 11 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 11 (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3).
SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several gro
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wth factor receptors and cytokines.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3/SH2 adaptor activity

Biological Process: brain development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; genitalia development; heart development; inner ear development; leukocyte migration; phosphoinositide-mediated signaling; platelet activation; regulation of cell adhesion mediated by integrin; regulation of phosphoinositide 3-kinase cascade; regulation of protein complex assembly; T cell costimulation

Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1
 PTPN11 ELISA Kit
 PTPN11 Recombinant
 PTPN11 Antibody
 PTP2C ELISA Kit
 PTP2C Recombinant
 PTP2C Antibody
 SHPTP2 ELISA Kit
 SHPTP2 Recombinant
 SHPTP2 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 12

 Tyrosine-protein phosphatase non-receptor type 12 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 12 Recombinant
 Tyrosine-protein phosphatase non-receptor type 12 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 12 (MPTP-PEST) (Protein-tyrosine phosphatase P19) (P19-PTP).
PTP-PEST: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non
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-receptor class 4 subfamily.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: cytoplasm; cytosol; plasma membrane; podosome

Molecular Function: phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding

Biological Process: protein amino acid dephosphorylation; regulation of epidermal growth factor receptor signaling pathway
 Ptpn12 ELISA Kit
 Ptpn12 Recombinant
 Ptpn12 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 13

 Tyrosine-protein phosphatase non-receptor type 13 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 13 Recombinant
 Tyrosine-protein phosphatase non-receptor type 13 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 13 (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1).
PTPN13: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-rece
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ptor)

Chromosomal Location of Human Ortholog: 4q21.3

Cellular Component: cytoplasm; lamellipodium; nucleus; plasma membrane

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation; regulation of phosphoinositide 3-kinase cascade
 PTPN13 ELISA Kit
 PTPN13 Recombinant
 PTPN13 Antibody
 PNP1 ELISA Kit
 PNP1 Recombinant
 PNP1 Antibody
 PTP1E ELISA Kit
 PTP1E Recombinant
 PTP1E Antibody
 PTPL1 ELISA Kit
 PTPL1 Recombinant
 PTPL1 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 14

 Tyrosine-protein phosphatase non-receptor type 14 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 14 Recombinant
 Tyrosine-protein phosphatase non-receptor type 14 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 14 (Protein-tyrosine phosphatase pez).
PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Com
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ponent: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; transcription cofactor activity

Biological Process: lymphangiogenesis; negative regulation of cell proliferation; protein amino acid dephosphorylation; regulation of protein export from nucleus

Disease: Choanal Atresia And Lymphedema
 PTPN14 ELISA Kit
 PTPN14 Recombinant
 PTPN14 Antibody
 PEZ ELISA Kit
 PEZ Recombinant
 PEZ Antibody
 PTPD2 ELISA Kit
 PTPD2 Recombinant
 PTPD2 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 18

 Tyrosine-protein phosphatase non-receptor type 18 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 18 Recombinant
 Tyrosine-protein phosphatase non-receptor type 18 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 18 (Brain-derived phosphatase).
BDP1: a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor
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-derived cell lines.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 2q21.1

Molecular Function: protein binding

Biological Process: protein amino acid dephosphorylation
 PTPN18 ELISA Kit
 PTPN18 Recombinant
 PTPN18 Antibody
 BDP1 ELISA Kit
 BDP1 Recombinant
 BDP1 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 2

 Tyrosine-protein phosphatase non-receptor type 2 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 2 Recombinant
 Tyrosine-protein phosphatase non-receptor type 2 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 2 (Protein-tyrosine phosphatase PTP-2) (MPTP).
PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.

Protein type: EC 3.1.3.48;
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Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: endoplasmic reticulum; ER-Golgi intermediate compartment; nucleus; plasma membrane

Molecular Function: integrin binding; non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; syntaxin binding

Biological Process: B cell differentiation; erythrocyte differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of macrophage differentiation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of gluconeogenesis; protein amino acid dephosphorylation; T cell differentiation
 Ptpn2 ELISA Kit
 Ptpn2 Recombinant
 Ptpn2 Antibody
 Ptpt ELISA Kit
 Ptpt Recombinant
 Ptpt Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 20

 Tyrosine-protein phosphatase non-receptor type 20 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 20 Recombinant
 Tyrosine-protein phosphatase non-receptor type 20 Antibody
PTPN20A: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis An
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tigen (CTA); EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
 Ptpn20 ELISA Kit
 Ptpn20 Recombinant
 Ptpn20 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 21

 Tyrosine-protein phosphatase non-receptor type 21 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 21 Recombinant
 Tyrosine-protein phosphatase non-receptor type 21 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 21 (Protein-tyrosine phosphatase 2E).
PTPN21: is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytos
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keletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Molecular Function: protein tyrosine phosphatase activity
 Ptpn21 ELISA Kit
 Ptpn21 Recombinant
 Ptpn21 Antibody
 Ptp2e ELISA Kit
 Ptp2e Recombinant
 Ptp2e Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 22

 Tyrosine-protein phosphatase non-receptor type 22 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 22 Recombinant
 Tyrosine-protein phosphatase non-receptor type 22 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 22 (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP).
PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates th
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e SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytoplasm; internal side of plasma membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: kinase binding; phosphoric monoester hydrolase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding; ubiquitin protein ligase binding

Biological Process: lipopolysaccharide-mediated signaling pathway; negative regulation of autophagy; negative regulation of JNK activity; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of interferon type I production; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein amino acid dephosphorylation; regulation of innate immune response; regulation of natural killer cell proliferation; response to lipopolysaccharide; T cell differentiation

Disease: Diabetes Mellitus, Insulin-dependent; Rheumatoid Arthritis; Systemic Lupus Erythematosus
 PTPN22 ELISA Kit
 PTPN22 Recombinant
 PTPN22 Antibody
 PTPN8 ELISA Kit
 PTPN8 Recombinant
 PTPN8 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 23

 Tyrosine-protein phosphatase non-receptor type 23 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 23 Recombinant
 Tyrosine-protein phosphatase non-receptor type 23 Antibody
PTPN23: May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: cytoplasm; early endosome; endosome; nucleoplasm; nucleus

Molecular F
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unction: protein kinase binding; protein tyrosine phosphatase activity

Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body pathway
 Ptpn23 ELISA Kit
 Ptpn23 Recombinant
 Ptpn23 Antibody
 Kiaa1471 ELISA Kit
 Kiaa1471 Recombinant
 Kiaa1471 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 3

 Tyrosine-protein phosphatase non-receptor type 3 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 3 Recombinant
 Tyrosine-protein phosphatase non-receptor type 3 Antibody
PTPN3: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: cytoplasm; internal side of plasma membrane

Molecular Function:
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ATPase binding; phosphotyrosine binding; protein tyrosine phosphatase activity; sodium channel regulator activity

Biological Process: negative regulation of membrane protein ectodomain proteolysis; negative regulation of mitotic cell cycle; protein amino acid dephosphorylation
 Ptpn3 ELISA Kit
 Ptpn3 Recombinant
 Ptpn3 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 4

 Tyrosine-protein phosphatase non-receptor type 4 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 4 Recombinant
 Tyrosine-protein phosphatase non-receptor type 4 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 4 (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1).
PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromoso
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mal Location of Human Ortholog: 2q14.2

Cellular Component: cytoplasm; internal side of plasma membrane

Molecular Function: protein binding

Biological Process: protein amino acid dephosphorylation
 PTPN4 ELISA Kit
 PTPN4 Recombinant
 PTPN4 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 5

 Tyrosine-protein phosphatase non-receptor type 5 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 5 Recombinant
 Tyrosine-protein phosphatase non-receptor type 5 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 5 (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP).
STEP: a non-receptor protein-tyrosine phosphatase. STEP (striatum enriched phosphatase) Contains a single phosphatase catalytic domain located at the C-terminus. Two alternatively-spliced messages have been described.

Prot
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ein type: EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: integral to membrane

Molecular Function: phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation
 PTPN5 ELISA Kit
 PTPN5 Recombinant
 PTPN5 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 6

 Tyrosine-protein phosphatase non-receptor type 6 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 6 Recombinant
 Tyrosine-protein phosphatase non-receptor type 6 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 6 (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1).
SHP-1: an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms
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have been described.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: alpha-beta T cell receptor complex; cytoplasm; intercellular junction; nucleolus; nucleus

Molecular Function: cell adhesion molecule binding; natural killer cell lectin-like receptor binding; phosphotyrosine binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; SH2 domain binding; SH3 domain binding; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: abortive mitotic cell cycle; B cell receptor signaling pathway; cell differentiation; cell proliferation; cytokine and chemokine mediated signaling pathway; hemopoietic progenitor cell differentiation; natural killer cell mediated cytotoxicity; negative regulation of B cell receptor signaling pathway; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; platelet formation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid dephosphorylation; regulation of B cell differentiation; regulation of release of sequestered calcium ion into cytosol
 Ptpn6 ELISA Kit
 Ptpn6 Recombinant
 Ptpn6 Antibody
 Hcp ELISA Kit
 Hcp Recombinant
 Hcp Antibody
 Hcph ELISA Kit
 Hcph Recombinant
 Hcph Antibody
 Ptp1C ELISA Kit
 Ptp1C Recombinant
 Ptp1C Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 61F

 Tyrosine-protein phosphatase non-receptor type 61F ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 61F Recombinant
 Tyrosine-protein phosphatase non-receptor type 61F Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 61F (dPTP61F).
Non-receptor protein tyrosine phosphatase required for maintaining Dock in its non-phosphorylated state.
 Ptp61F ELISA Kit
 Ptp61F Recombinant
 Ptp61F Antibody
 CG9181 ELISA Kit
 CG9181 Recombinant
 CG9181 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 7

 Tyrosine-protein phosphatase non-receptor type 7 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 7 Recombinant
 Tyrosine-protein phosphatase non-receptor type 7 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type 7 (Hematopoietic protein-tyrosine phosphatase) (HEPTP).
HePTP: a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown
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to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: cytoplasm; cytosol; internal side of plasma membrane

Molecular Function: protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation
 Ptpn7 ELISA Kit
 Ptpn7 Recombinant
 Ptpn7 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type 9

 Tyrosine-protein phosphatase non-receptor type 9 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type 9 Recombinant
 Tyrosine-protein phosphatase non-receptor type 9 Antibody
PTPN9: Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Cellular Component: cytoplasm

Molecular Function: prote
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in tyrosine phosphatase activity
 Ptpn9 ELISA Kit
 Ptpn9 Recombinant
 Ptpn9 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type eak-6

 Tyrosine-protein phosphatase non-receptor type eak-6 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type eak-6 Recombinant
 Tyrosine-protein phosphatase non-receptor type eak-6 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type eak-6 (Enhancer of akt-1 null 6).
Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.
 eak-6 ELISA Kit
 eak-6 Recombinant
 eak-6 Antibody
 F10G8.4 ELISA Kit
 F10G8.4 Recombinant
 F10G8.4 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type ptp-2

 Tyrosine-protein phosphatase non-receptor type ptp-2 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type ptp-2 Recombinant
 Tyrosine-protein phosphatase non-receptor type ptp-2 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type ptp-2 (Protein-tyrosine phosphatase 2).
Involved in embryonic and larval development (PubMed:9472025, PubMed:20380830). Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP) (PubMed:9472025, PubMed:20380830). During the formation of neuromuscular junctions at the l
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arval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15 (PubMed:16495308). Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1 (PubMed:11689700). Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23 (PubMed:9472025, PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100).
 ptp-2 ELISA Kit
 ptp-2 Recombinant
 ptp-2 Antibody
 F59G1.5 ELISA Kit
 F59G1.5 Recombinant
 F59G1.5 Antibody
Table BarTOPTable Bar
 

Tyrosine-protein phosphatase non-receptor type substrate 1

 Tyrosine-protein phosphatase non-receptor type substrate 1 ELISA Kit
 Tyrosine-protein phosphatase non-receptor type substrate 1 Recombinant
 Tyrosine-protein phosphatase non-receptor type substrate 1 Antibody
Also known as Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a).
SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebella
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r neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protein phosphorylated amino acid binding

Biological Process: actin filament organization; cell migration; cell-matrix adhesion; cytoskeleton organization and biogenesis; hemopoietic progenitor cell differentiation; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis
 Sirpa ELISA Kit
 Sirpa Recombinant
 Sirpa Antibody
 Bit ELISA Kit
 Bit Recombinant
 Bit Antibody
 Mfr ELISA Kit
 Mfr Recombinant
 Mfr Antibody
 Ptpns1 ELISA Kit
 Ptpns1 Recombinant
 Ptpns1 Antibody
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Proteins Root Name Listing
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