| Ubiquitin-like-conjugating enzyme ATG3 ELISA Kit|
Ubiquitin-like-conjugating enzyme ATG3 Recombinant
Ubiquitin-like-conjugating enzyme ATG3 Antibody
|Also known as Ubiquitin-like-conjugating enzyme ATG3 (Autophagy-related protein 3) (APG3-like). |
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conju
gate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of atg12 to itself, atg12 conjugation to atg3 playing a role in mitochondrial homeostasis but not in autophagy. atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with atg3 ().
| atg3 ELISA Kit|
| apg3l ELISA Kit|