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Ubiquitin-like modifier-activating enzyme

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Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system .

Below are the list of possible Ubiquitin-like modifier-activating enzyme products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ubiquitin-like modifier-activating enzyme 1

 Ubiquitin-like modifier-activating enzyme 1 ELISA Kit
 Ubiquitin-like modifier-activating enzyme 1 Recombinant
 Ubiquitin-like modifier-activating enzyme 1 Antibody
Also known as Ubiquitin-like modifier-activating enzyme 1 (Protein A1S9) (Ubiquitin-activating enzyme E1).
UBE1: an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temper
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ature-sensitive defect in DNA synthesis, and thus may function in DNA repair.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm; cytosol; desmosome; endosome membrane; heterochromatin; lysosomal membrane; mitochondrion; nucleus; rough endoplasmic reticulum membrane

Molecular Function: protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity

Biological Process: modification-dependent protein catabolic process; response to DNA damage stimulus

Disease: Spinal Muscular Atrophy, X-linked 2
 UBA1 ELISA Kit
 UBA1 Recombinant
 UBA1 Antibody
 A1S9T ELISA Kit
 A1S9T Recombinant
 A1S9T Antibody
 UBE1 ELISA Kit
 UBE1 Recombinant
 UBE1 Antibody
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Ubiquitin-like modifier-activating enzyme 1 Y

 Ubiquitin-like modifier-activating enzyme 1 Y ELISA Kit
 Ubiquitin-like modifier-activating enzyme 1 Y Recombinant
 Ubiquitin-like modifier-activating enzyme 1 Y Antibody
Also known as Ubiquitin-like modifier-activating enzyme 1 Y (Ubiquitin-activating enzyme E1) (Ubiquitin-activating enzyme E1 Y).
Ube1y1: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia. Belongs to the ubiquitin-activating E1 family.

Cellular Component: cytosol; nucleus

Molecular Function: ubiquitin activatin
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g enzyme activity; ubiquitin-protein ligase activity

Biological Process: modification-dependent protein catabolic process
 Uba1y ELISA Kit
 Uba1y Recombinant
 Uba1y Antibody
 Sby ELISA Kit
 Sby Recombinant
 Sby Antibody
 Ube1ay ELISA Kit
 Ube1ay Recombinant
 Ube1ay Antibody
 Ube1y ELISA Kit
 Ube1y Recombinant
 Ube1y Antibody
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Ubiquitin-like modifier-activating enzyme 5

 Ubiquitin-like modifier-activating enzyme 5 ELISA Kit
 Ubiquitin-like modifier-activating enzyme 5 Recombinant
 Ubiquitin-like modifier-activating enzyme 5 Antibody
Also known as Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5).
E1-like enzyme which activates UFM1.
 GF23479 ELISA Kit
 GF23479 Recombinant
 GF23479 Antibody
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Ubiquitin-like modifier-activating enzyme 6

 Ubiquitin-like modifier-activating enzyme 6 ELISA Kit
 Ubiquitin-like modifier-activating enzyme 6 Recombinant
 Ubiquitin-like modifier-activating enzyme 6 Antibody
Also known as Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2).
UBE1L2: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryo
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nic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Belongs to the ubiquitin-activating E1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: FAT10 activating enzyme activity; protein binding

Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process
 UBA6 ELISA Kit
 UBA6 Recombinant
 UBA6 Antibody
 MOP4 ELISA Kit
 MOP4 Recombinant
 MOP4 Antibody
 UBE1L2 ELISA Kit
 UBE1L2 Recombinant
 UBE1L2 Antibody
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Ubiquitin-like modifier-activating enzyme 7

 Ubiquitin-like modifier-activating enzyme 7 ELISA Kit
 Ubiquitin-like modifier-activating enzyme 7 Recombinant
 Ubiquitin-like modifier-activating enzyme 7 Antibody
Also known as Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog).
UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: cytosol; nucleoplasm; nucleus >>>
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Molecular Function: ISG15 activating enzyme activity; protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity

Biological Process: bypass DNA synthesis; ISG15-protein conjugation; modification-dependent protein catabolic process; negative regulation of interferon type I production; protein modification process
 UBA7 ELISA Kit
 UBA7 Recombinant
 UBA7 Antibody
 UBE1L ELISA Kit
 UBE1L Recombinant
 UBE1L Antibody
 UBE2 ELISA Kit
 UBE2 Recombinant
 UBE2 Antibody
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Ubiquitin-like modifier-activating enzyme atg7

 Ubiquitin-like modifier-activating enzyme atg7 ELISA Kit
 Ubiquitin-like modifier-activating enzyme atg7 Recombinant
 Ubiquitin-like modifier-activating enzyme atg7 Antibody
Also known as Ubiquitin-like modifier-activating enzyme atg7 (ATG12-activating enzyme E1 atg7) (Autophagy-related protein 7).
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the a
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tg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity ().
 atg7 ELISA Kit
 atg7 Recombinant
 atg7 Antibody
 AN7428 ELISA Kit
 AN7428 Recombinant
 AN7428 Antibody
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