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Ubiquitin-protein ligase

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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation .

Below are the list of possible Ubiquitin-protein ligase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Ubiquitin-protein ligase E3A

 Ubiquitin-protein ligase E3A ELISA Kit
 Ubiquitin-protein ligase E3A Recombinant
 Ubiquitin-protein ligase E3A Antibody
Also known as Ubiquitin-protein ligase E3A (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54).
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy,
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absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
 UBE3A ELISA Kit
 UBE3A Recombinant
 UBE3A Antibody
 E6AP ELISA Kit
 E6AP Recombinant
 E6AP Antibody
 EPVE6AP ELISA Kit
 EPVE6AP Recombinant
 EPVE6AP Antibody
 HPVE6A ELISA Kit
 HPVE6A Recombinant
 HPVE6A Antibody
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Ubiquitin-protein ligase E3B

 Ubiquitin-protein ligase E3B ELISA Kit
 Ubiquitin-protein ligase E3B Recombinant
 Ubiquitin-protein ligase E3B Antibody
Also known as Ubiquitin-protein ligase E3B (HECT-type ubiquitin transferase E3B).
UBE3B: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase;
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Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
 Ube3b ELISA Kit
 Ube3b Recombinant
 Ube3b Antibody
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Ubiquitin-protein ligase E3C

 Ubiquitin-protein ligase E3C ELISA Kit
 Ubiquitin-protein ligase E3C Recombinant
 Ubiquitin-protein ligase E3C Antibody
Also known as Ubiquitin-protein ligase E3C (HECT-type ubiquitin transferase E3C).
UBE3C: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. 3 isoforms of the human protein are produced by alternative splicing.

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Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Cellular Component: cytoplasm; nucleus

Molecular Function: ubiquitin-protein ligase activity

Biological Process: protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
 Ube3c ELISA Kit
 Ube3c Recombinant
 Ube3c Antibody
 Kiaa0010 ELISA Kit
 Kiaa0010 Recombinant
 Kiaa0010 Antibody
 Kiaa10 ELISA Kit
 Kiaa10 Recombinant
 Kiaa10 Antibody
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