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UV radiation resistance associated protein

Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events. Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion. In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (By similarity).

Below are the list of possible UV radiation resistance associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

UV radiation resistance associated protein

 UV radiation resistance associated protein ELISA Kit
 UV radiation resistance associated protein Recombinant
 UV radiation resistance associated protein Antibody
UVRAG: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver.

Protein type: Autophagy

Cellular Component: centrosome; early endosome; endoplasmic r
eticulum; endosome; late endosome; lysosome; lytic vacuole; midbody; phagocytic vesicle; protein complex

Molecular Function: protein binding; SH3 domain binding; SNARE binding

Biological Process: autophagy; centrosome organization and biogenesis; chromosome segregation; DNA repair; entry of virus into host cell; maintenance of Golgi localization; receptor catabolic process; regulation of cytokinesis; retrograde vesicle-mediated transport, Golgi to ER; spindle organization and biogenesis
 Uvrag ELISA Kit
 Uvrag Recombinant
 Uvrag Antibody
 Uvrag1 ELISA Kit
 Uvrag1 Recombinant
 Uvrag1 Antibody
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