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Vang-like protein

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Below are the list of possible Vang-like protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Vang-like protein 1

 Vang-like protein 1 ELISA Kit
 Vang-like protein 1 Recombinant
 Vang-like protein 1 Antibody
Also known as Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1).
VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and s
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pinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p13.1

Molecular Function: protein binding

Disease: Neural Tube Defects; Sacral Defect With Anterior Meningocele
 VANGL1 ELISA Kit
 VANGL1 Recombinant
 VANGL1 Antibody
 STB2 ELISA Kit
 STB2 Recombinant
 STB2 Antibody
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Vang-like protein 2

 Vang-like protein 2 ELISA Kit
 Vang-like protein 2 Recombinant
 Vang-like protein 2 Antibody
Also known as Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2).
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1,
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DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure

Disease: Neural Tube Defects
 VANGL2 ELISA Kit
 VANGL2 Recombinant
 VANGL2 Antibody
 KIAA1215 ELISA Kit
 KIAA1215 Recombinant
 KIAA1215 Antibody
 STB1 ELISA Kit
 STB1 Recombinant
 STB1 Antibody
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Vang-like protein 2-A

 Vang-like protein 2-A ELISA Kit
 Vang-like protein 2-A Recombinant
 Vang-like protein 2-A Antibody
Also known as Vang-like protein 2-A (Protein strabismus-A) (Van Gogh-like protein 2-A) (Xstrabismus-A) (Xstbm-A).
Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates con
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vergent extension cell movements in both dorsal mesoderm and neural tissue during gastrulation, without affecting cell fate. Regulates neural fold closure during neurulation (PubMed:11867525, PubMed:11780127, PubMed:12421719). May be required for cell surface localization of fzd3 and fzd6 in the inner ear ().
 vangl2-a ELISA Kit
 vangl2-a Recombinant
 vangl2-a Antibody
 stbm-a ELISA Kit
 stbm-a Recombinant
 stbm-a Antibody
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Vang-like protein 2-B

 Vang-like protein 2-B ELISA Kit
 Vang-like protein 2-B Recombinant
 Vang-like protein 2-B Antibody
Also known as Vang-like protein 2-B (Protein strabismus-B) (Van Gogh-like protein 2-B) (Xstrabismus-B) (Xstbm-B).
Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruite dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates co
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nvergent extension in both dorsal mesoderm and neural tissue without affecting cell fate. Regulates neural fold closure during neurulation (PubMed:12074560, PubMed:15854914). May be required for cell surface localization of fzd3 and fzd6 in the inner ear ().
 vangl2-b ELISA Kit
 vangl2-b Recombinant
 vangl2-b Antibody
 stbm-a ELISA Kit
 stbm-a Recombinant
 stbm-a Antibody
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