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Variant-silencing SET domain-containing protein

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Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response. Represses expression of both var mRNA and antisense long non-coding RNA.

Below are the list of possible Variant-silencing SET domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Variant-silencing SET domain-containing protein

 Variant-silencing SET domain-containing protein ELISA Kit
 Variant-silencing SET domain-containing protein Recombinant
 Variant-silencing SET domain-containing protein Antibody
Also known as Variant-silencing SET domain-containing protein (PfSETvs) (SET domain-containing protein 2) (PfSET2).
Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59
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other var genes are silenced. The parasite then switches to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response. Represses expression of both var mRNA and antisense long non-coding RNA.
 SETVS ELISA Kit
 SETVS Recombinant
 SETVS Antibody
 SET2 ELISA Kit
 SET2 Recombinant
 SET2 Antibody
 MAL13P1.122 ELISA Kit
 MAL13P1.122 Recombinant
 MAL13P1.122 Antibody
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